https://scholars.lib.ntu.edu.tw/handle/123456789/585081
標題: | Successful treatment of oral verrucous hyperplasia with topical 5-aminolevulinic acid-mediated photodynamic therapy | 作者: | HSIN-MING CHEN Chen C.-T. Yang H. YEN-PING KUO Kuo Y.-S. Lan W.-H. YI-PING WANG Tsai T. CHUN-PIN CHIANG |
公開日期: | 2004 | 卷: | 40 | 期: | 6 | 起(迄)頁: | 630-637 | 來源出版物: | Oral Oncology | 摘要: | Previous studies have shown a selective accumulation of 5-aminolevulinic acid (ALA)-derived protoporphrin IX (PpIX) in oral premalignant and malignant tissues. This provides a biologic rationale for the clinical use of ALA-mediated PDT (ALA-PDT) for oral premalignant and malignant lesions. In this study, five patients with oral verrucous hyperplasia (OVH) were treated with a new protocol of ALA-PDT composed of multiple 3-min irradiations with a light emitting diode (LED) red light at 635±5 nm separated with several 3-min rests for a total of 1000 s (fluence rate, 100 mW/cm2; light exposure dose, 100 J/cm2) after topical application of 20% ALA for 1.5 or 2 h. Topical ALA-PDT was repeated once a week until the complete regression of the lesion. Complete regression of all OVH lesions was observed after 1-3 treatments (average, 2 treatments) of topical ALA-PDT. At an average follow-up of 5.6 months (range, 3-11 months), all the five OVH patients were free of tumor recurrence. We conclude that topical ALA-PDT with fractionated irradiations by an LED red light at 635±5 nm is an effective and successful treatment modality for OVH. ? 2004 Elsevier Ltd. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-1842424985&doi=10.1016%2fj.oraloncology.2003.12.010&partnerID=40&md5=5c23f67d97f69437ecd98985de07b747 https://scholars.lib.ntu.edu.tw/handle/123456789/585081 |
ISSN: | 1368-8375 | DOI: | 10.1016/j.oraloncology.2003.12.010 | SDG/關鍵字: | aminolevulinic acid; analgesic agent; carbomer; carbopol 971p; poloxamer; protoporphyrin; unclassified drug; adult; article; cancer radiotherapy; cancer regression; clinical article; clinical protocol; clinical trial; controlled clinical trial; controlled study; drug efficacy; drug formulation; follow up; human; human tissue; leukoplakia; light emitting diode; male; oral verrucous hyperplasia; pain; photodynamic therapy; priority journal; radiation dose; red light; treatment outcome; tumor recurrence; Adult; Aminolevulinic Acid; Humans; Hyperplasia; Male; Middle Aged; Mouth Diseases; Mouth Neoplasms; Photochemotherapy; Photosensitizing Agents; Precancerous Conditions; Spectrometry, Fluorescence; Treatment Outcome; Warts |
顯示於: | 牙醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。