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  1. NTU Scholars
  2. 醫學院
  3. 醫學院附設醫院 (臺大醫院)
Please use this identifier to cite or link to this item: https://scholars.lib.ntu.edu.tw/handle/123456789/585404
Title: Seroprevalence survey of selective anti-neuronal autoantibodies in patients with first-episode schizophrenia and chronic schizophrenia
Authors: Chen C.-H.
Cheng M.-C.
CHIH-MIN LIU 
CHEN-CHUNG LIU 
Lin K.-H.
HAI-GWO HWU 
Issue Date: 2017
Journal Volume: 190
Start page/Pages: 28-31
Source: Schizophrenia Research
Abstract: 
Autoimmune encephalopathy caused by autoantibodies against neuronal cell-surface proteins in the brain is a newly discovered disease category associated with psychiatric disorders. Correct diagnosis of this condition relies on the detection of specific autoantibodies in the blood or cerebral spinal fluid in addition to the clinical presentations. The study aimed to understand the seroprevalence of selective anti-neuronal autoantibodies in our patients with schizophrenia. First, we screened for six anti-neuronal autoantibodies in an archived blood sample collected from patients with the first-episode schizophrenia. The six autoantibodies including antibodies against N-methyl-D-aspartate (NMDA) receptor, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors 1 and 2, γ-butyric acid receptor type B1 (GABARB1), leucine-rich glioma inactivated-1 (LGI1) protein, and contactin-associated protein-like 2 (CASPR2) protein. A total of 78 plasma samples (46 males and 32 females) were investigated; however, no positive case was identified. In this second study, we screened anti-NMDA receptor autoantibodies in a blood sample of 234 patients with chronic schizophrenia (133 females and 101 males) including 48 patients defined as treatment resistance. None of this sample was detected as positive. The negative findings in this study suggest that the seroprevalence of autoantibodies against neuronal surface proteins might be low in patients diagnosed with schizophrenia. ? 2017 Elsevier B.V.
URI: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85015872331&doi=10.1016%2fj.schres.2017.03.012&partnerID=40&md5=ebff873229fbd9b5dff8d41b140d16ea
https://scholars.lib.ntu.edu.tw/handle/123456789/585404
ISSN: 9209964
DOI: 10.1016/j.schres.2017.03.012
SDG/Keyword: 4 aminobutyric acid receptor; AMPA receptor; AMPA receptor 1; AMPA receptor 2; contactin; contactin associated protein like 2 protein; gamma butyric acid receptor type B1; leucine; leucine rich glioma inactivated 1 protein; n methyl dextro aspartic acid receptor; n methyl dextro aspartic acid receptor antibody; unclassified drug; autoantibody; nerve protein; adult; antibody blood level; Article; controlled study; disease course; disease duration; DSM-IV; DSM-IV-TR; female; first episode schizophrenia; human; immunohistochemistry; informed consent; major clinical study; male; pathogenesis; priority journal; protein blood level; schizophrenia; seroprevalence; acute disease; blood; chronic disease; clinical trial; drug resistance; immunology; middle aged; multicenter study; prevalence; schizophrenia; seroepidemiology; young adult; Acute Disease; Adult; Autoantibodies; Chronic Disease; Drug Resistance; Female; Humans; Male; Middle Aged; Nerve Tissue Proteins; Prevalence; Schizophrenia; Seroepidemiologic Studies; Young Adult
[SDGs]SDG3
Appears in Collections:醫學院附設醫院 (臺大醫院)

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臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of “NTU Repository” with “Academic Hub” to form NTU Scholars.

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開放取用是從使用者角度提升資訊取用性的社會運動,應用在學術研究上是透過將研究著作公開供使用者自由取閱,以促進學術傳播及因應期刊訂購費用逐年攀升。同時可加速研究發展、提升研究影響力,NTU Scholars即為本校的開放取用典藏(OA Archive)平台。(點選深入了解OA)

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