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  1. NTU Scholars
  2. 醫學院
  3. 醫學院附設醫院 (臺大醫院)
Please use this identifier to cite or link to this item: https://scholars.lib.ntu.edu.tw/handle/123456789/585427
Title: Reduced structural integrity and functional lateralization of the dorsal language pathway correlate with hallucinations in schizophrenia: A combined diffusion spectrum imaging and functional magnetic resonance imaging study
Authors: Wu C.-H.
Hwang T.-J.
Chen P.-J.
Chou T.-L.
Hsu Y.-C.
Liu C.-M.
Wang H.-L.
Chen C.-M.
Hua M.-S.
HAI-GWO HWU 
Tseng W.-Y.I.
Issue Date: 2014
Journal Volume: 224
Journal Issue: 3
Start page/Pages: 303-310
Source: Psychiatry Research - Neuroimaging
Abstract: 
Recent studies suggest that structural and functional alterations of the language network are associated with auditory verbal hallucinations (AVHs) in schizophrenia. However, the ways in which the underlying structure and function of the network are altered and how these alterations are related to each other remain unclear. To elucidate this, we used diffusion spectrum imaging (DSI) to reconstruct the dorsal and ventral pathways and employed functional magnetic resonance imaging (fMRI) in a semantic task to obtain information about the functional activation in the corresponding regions in 18 patients with schizophrenia and 18 matched controls. The results demonstrated decreased structural integrity in the left ventral, right ventral and right dorsal tracts, and decreased functional lateralization of the dorsal pathway in schizophrenia. There was a positive correlation between the microstructural integrity of the right dorsal pathway and the functional lateralization of the dorsal pathway in patients with schizophrenia. Additionally, both functional lateralization of the dorsal pathway and microstructural integrity of the right dorsal pathway were negatively correlated with the scores of the delusion/hallucination symptom dimension. Our results suggest that impaired structural integrity of the right dorsal pathway is related to the reduction of functional lateralization of the dorsal pathway, and these alterations may aggravate AVHs in schizophrenia. ? 2014 Elsevier Ireland Ltd. All rights reserved.
URI: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84935446045&doi=10.1016%2fj.pscychresns.2014.08.010&partnerID=40&md5=26c85046dddd43c3ca4390538b5233be
https://scholars.lib.ntu.edu.tw/handle/123456789/585427
ISSN: 9254927
DOI: 10.1016/j.pscychresns.2014.08.010
Appears in Collections:醫學院附設醫院 (臺大醫院)

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臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

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