Use of H-1 Antihistamine in Dermatology: More than Itch and Urticaria Control: A Systematic review
Journal
Dermatology and Therapy
Journal Volume
11
Journal Issue
3
Pages
719-732
Date Issued
2021
Author(s)
Hsieh C.-Y.
Abstract
H-1 antihistamines are commonly used in dermatological practice for itch and urticaria control. The widespread expression of H-1 receptor on different cells in the skin and various biologic functions of H-1 antihistamines indicate the possible treatment potentials of H-1 antihistamines in dermatology. A literature search was performed on PubMed and Embase, targeting articles reporting use of antihistamine for purposes other than itch and urticaria control in dermatological practice. Several off-label usages of antihistamines were identified, including alopecia, acne, Darier disease, eosinophilic dermatoses, paraneoplastic dermatoses, psoriasis, lichen nitidus, radiation dermatitis, skin dysesthesia, and cutaneous malignancies. Additional benefits were observed when H-1 antihistamines were used either alone or in combination with other therapeutic modalities. Although various novel uses of H-1 antihistamines have been uncovered, the evidence level of most included studies is weak. Further randomized control trials are warranted to better evaluate the efficacy and dosage of H-1 antihistamine for dermatological disorders. ? 2021, The Author(s).
Subjects
Anti-inflammation; Dermatology; H-1 antihistamines; Off-label usages; Pleiotropic effects
SDGs
Other Subjects
analgesic agent; antihistaminic agent; astemizole; azelastine; bepotastine; bilastine; bromocriptine; cetirizine; chlorpheniramine; clemastine; clobetasol; corticosteroid; cyproheptadine; desloratadine; diphencyprone; diphenhydramine; ebastine; fexofenadine; gabapentin; histamine H1 receptor antagonist; hydroxyzine; intercellular adhesion molecule 1; isotretinoin; ketotifen; levocetirizine; loratadine; montelukast; oxatomide; pizotifen; pregabalin; ranitidine; sertraline; steroid; terfenadine; acanthosis nigricans; acne; acromegaly; adjuvant therapy; adult; alopecia areata; analgesic activity; antiinflammatory activity; antiviral activity; atopic dermatitis; basophil; bullous skin disease; burning sensation; chemotaxis; clinical practice; corticosteroid therapy; Darier disease; drug mechanism; dysesthesia; Embase; eosinophil; eosinophilic fasciitis; eosinophilic pustular folliculitis; erythromelalgia; folliculitis; growth hormone release; human; hypereosinophilic syndrome; in vitro study; Kaposi sarcoma; keratinocyte; lichen (disease); lichen planopilaris; lichenoid eruption; male; male type alopecia; mast cell; mediator release; Medline; melanoma; middle aged; neutrophil chemotaxis; protein expression; protein secretion; pruritus; psoriasis; radiation dermatitis; randomized controlled trial (topic); Review; scalp dysesthesia; sebum secretion; skin disease; systematic review; treatment response; unspecified side effect; urticaria; Wells syndrome
Publisher
Adis
Type
review