https://scholars.lib.ntu.edu.tw/handle/123456789/585978
標題: | HLA-Cw1 and Psoriasis | 作者: | Huang Y.-W. TSEN-FANG TSAI |
公開日期: | 2021 | 出版社: | Adis | 卷: | 22 | 期: | 3 | 起(迄)頁: | 339-347 | 來源出版物: | American Journal of Clinical Dermatology | 摘要: | Psoriasis is a chronic inflammatory skin condition with regional and ethnic differences in its prevalence and clinical manifestations. Human leukocyte antigen (HLA)-Cw6 is the disease allele conferring the greatest risk to psoriasis, but its prevalence is lower in Asian individuals. Recent studies have found associations between HLA-Cw1 and some Asian populations with psoriasis, especially Southern Chinese. HLA-Cw6 was associated with type I early-onset psoriasis, guttate psoriasis, Koebner phenomenon, and better response to methotrexate, interleukin (IL)-12/23, IL-17, and IL-23 targeting drugs. In contrast, HLA-Cw1 positivity has been associated with erythrodermic psoriasis, pustular psoriasis, and the axial type of psoriatic arthritis. Furthermore, HLA-Cw1 was more frequently associated with high-need patients who did not respond to conventional therapies. No known trigger factor nor autoantigen has been identified for HLA-Cw1 positivity. However, HLA-Cw1 has been linked to some viral agents. For example, cytotoxic T lymphocytes recognize multiple cytomegalovirus pp65-derived epitopes presented by HLA alleles, including HLA-C*01:02. In addition, cytomegalovirus can lead to severe exacerbation of psoriatic skin disease. The proposed interaction between viral infection, HLA-Cw1, and psoriasis is through the killer cell immunoglobulin-like receptors of natural killer cells. Given the diverse nature of psoriasis pathogenesis and the difference in HLA-Cw prevalence in different racial groups, more studies are needed to confirm the role of HLA-Cw1 in psoriasis. ? 2021, The Author(s), under exclusive licence to Springer Nature Switzerland AG part of Springer Nature. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100002178&doi=10.1007%2fs40257-020-00585-1&partnerID=40&md5=999d60276df1177143cc49b2d8e3c5f9 https://scholars.lib.ntu.edu.tw/handle/123456789/585978 |
ISSN: | 1175-0561 | DOI: | 10.1007/s40257-020-00585-1 | SDG/關鍵字: | cytomegalovirus antigen pp65; epitope; HLA C antigen; HLA Cw1 antigen; interleukin 12; interleukin 17; interleukin 23; killer cell immunoglobulin like receptor; methotrexate; unclassified drug; HLA C antigen; HLA-C*06 antigen; HLA-Cw1 antigen; Asian; comorbidity; Cytomegalovirus; cytotoxic T lymphocyte; disease exacerbation; erythrodermic psoriasis; ethnic difference; gene frequency; genetic association; guttate psoriasis; human; immune system; infectious agent; natural killer cell; nonhuman; priority journal; psoriasis; psoriatic arthritis; Review; allele; Asian continental ancestry group; genetic predisposition; genetic variation; genetics; immunology; pathology; psoriasis; psoriatic arthritis; severity of illness index; skin; virus infection; Alleles; Arthritis, Psoriatic; Asian Continental Ancestry Group; Comorbidity; Gene Frequency; Genetic Predisposition to Disease; Genetic Variation; HLA-C Antigens; Humans; Killer Cells, Natural; Psoriasis; Severity of Illness Index; Skin; Virus Diseases |
顯示於: | 醫學系 |
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