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  4. A single low-energy shockwave pulse opens blood-cerebrospinal fluid barriers and facilitates gastrodin delivery to alleviate epilepsy
 
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A single low-energy shockwave pulse opens blood-cerebrospinal fluid barriers and facilitates gastrodin delivery to alleviate epilepsy

Journal
Ultrasonics sonochemistry
Journal Volume
78
Date Issued
2021-10
Author(s)
Kung, Yi
MING-YEN HSIAO  
SHU-MEI YANG  
Wen, Tz-Yi
Chen, Moxian
Liao, Wei-Hao
CHUEH-HUNG WU  
Ao, Lijuan
WEN-SHIANG CHEN  
DOI
10.1016/j.ultsonch.2021.105730
URI
https://scholars.lib.ntu.edu.tw/handle/123456789/586002
URL
https://scholars.lib.ntu.edu.tw/handle/123456789/582770
Abstract
The blood-cerebrospinal fluid barrier (BCSFB) is another gatekeeper between systemic circulation and the central nervous system (CNS), mainly present at the boundary between choroid plexuses and the ventricular system. This study demonstrates BCSFB opening in rats by single pulse of low-energy focused shockwave (FSW, energy flux density 0.03 mJ/mm2, 2 × 106 microbubbles/kg) treatment at lateral ventricle, resulting in significantly elevated cerebrospinal fluid (CSF) concentrations of systemically-administered gastrodin (GTD) (4 times vs. control within 3 hrs) that remained detectable for 24 hrs. The FSW-GTD group had significantly lower Racine's scale (<4) and zero mortality (n = 30) after lithium-pilocarpine-induced epilepsy. Electrophysiological recordings showed decreased epileptiform discharges, and brain section histology revealed reduced inflammation, oxidative stress and apoptosis, when compared with groups without FSW (Racine's scale: 4 ∼ 5; mortality: 26.67 ∼ 36.67%). FSW-mediated BCSFB opening provides a promising alternative for controlled-delivery of therapeutics into the CNS, offering rapid and widespread medication distribution. The technique could by applied in the development of novel therapies for various CNS diseases.
Subjects
Alleviate epilepsy; Blood-cerebrospinal fluid barriers; Gastrodin; Single low-energy shockwave
SDGs

[SDGs]SDG3

Other Subjects
Blood; Brain; Cerebrospinal fluid; Electrophysiology; Neurology; Shock waves; Alleviate epilepsy; Blood-cerebrospinal fluid-barrier; Central nervous systems; Energy flux density; Gastrodin; Lower energies; Single low-energy shockwave; Single pulse; Systemic circulation; Ventricular systems; Cell death; alkaline phosphatase; chloral hydrate; gastrodin; glial fibrillary acidic protein; lithium chloride; malonaldehyde; pilocarpine; superoxide dismutase; benzyl alcohol derivative; gastrodin; glucoside; adult; animal experiment; animal model; animal tissue; apoptosis; Article; blood cerebrospinal fluid barrier; brain lateral ventricle; choroid plexus; circulation; controlled study; drug delivery system; electrocorticography; electroencephalogram; electrophysiological procedures; epilepsy; epileptic discharge; epileptic patient; feasibility study; histopathology; human; immunohistochemistry; inflammation; male; microbubble; mortality; nonhuman; oxidative stress; rat; seizure score; therapy effect; tonic clonic seizure; videorecording; animal; blood brain barrier; drug effect; metabolism; Animals; Benzyl Alcohols; Blood-Brain Barrier; Choroid Plexus; Epilepsy; Glucosides; Rats
Type
journal article

臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

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