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  4. Investigation of the Number of Tests Required for Assaying Plasma Biomarkers Associated with Alzheimer’s Disease Using Immunomagnetic Reduction
 
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Investigation of the Number of Tests Required for Assaying Plasma Biomarkers Associated with Alzheimer’s Disease Using Immunomagnetic Reduction

Journal
Neurology and Therapy
Date Issued
2021
Author(s)
Liu H.-C.
Chen H.-H.
Ho C.-S.
Chang J.-F.
Lin C.-C.
MING-JANG CHIU  
TA-FU CHEN  
Hu C.-J.
Yan S.-H.
Sun Y.
Yang S.-Y.
DOI
10.1007/s40120-021-00280-1
URI
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114775251&doi=10.1007%2fs40120-021-00280-1&partnerID=40&md5=4ca2d7d562e592cfecbee20f55fb5215
https://scholars.lib.ntu.edu.tw/handle/123456789/586638
Abstract
Introduction: Concentrations of plasma biomarkers associated with Alzheimer’s disease have been reported to be as low as several tens of picograms/milliliter (pg/ml). However, in assays measuring these biomarkers, it is likely that repeated measurements are necessary to obtain reliable values. Methods: We performed assays as a single test or as duplicate, quadruplicate, fivefold and tenfold repeated tests, on samples spiked with different concentrations of amyloid β 1–40 (Aβ1–40; 1–1000?pg/ml), Aβ1–42 (1–30,000?pg/ml) and total Tau protein (T-Tau; 0.1–1000?pg/ml), with the aim to to calculate the coefficients of variation (CVs). Results: The results demonstrated common changes in the CVs with changes in the number of tests for a given sample: the CVs decreased with increases in the number of tests from one to ten. All CV values were distributed within the range of 0.35 to 15.5%; as such, the CV values were all lower than the acceptable value of 20%. Conclusion: Based on this study, a single assay of Aβ1–40, Aβ1–42 and T-Tau, respectively, provides reliable results in terms of the measurement of that plasma biomarker. ? 2021, The Author(s).
SDGs

[SDGs]SDG3

Other Subjects
amyloid beta protein; amyloid beta protein[1-40]; amyloid beta protein[1-42]; biological marker; tau protein; aged; Alzheimer disease; Article; blood sampling; brain size; controlled study; female; Geriatric Depression Scale; hippocampus; human; immunomagnetic separation; major clinical study; male; mathematical model; measurement repeatability; mild cognitive impairment; Mini Mental State Examination; neuropsychological test; plasma; protein blood level; volume
Type
journal article

臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of “NTU Repository” with “Academic Hub” to form NTU Scholars.

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開放取用是從使用者角度提升資訊取用性的社會運動,應用在學術研究上是透過將研究著作公開供使用者自由取閱,以促進學術傳播及因應期刊訂購費用逐年攀升。同時可加速研究發展、提升研究影響力,NTU Scholars即為本校的開放取用典藏(OA Archive)平台。(點選深入了解OA)

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