https://scholars.lib.ntu.edu.tw/handle/123456789/586672
標題: | Relationships Among and Predictive Values of Obesity, Inflammation Markers, and Disease Severity in Pediatric Patients with Obstructive Sleep Apnea Before and After Adenotonsillectomy | 作者: | Chuang, Hai-Hua Huang, Chung-Guei Chuang, Li-Pang Huang, Yu-Shu Chen, Ning-Hung Li, Hsueh-Yu Fang, Tuan-Jen Hsu, Jen-Fu HSIN-CHIH LAI Chen, Jau-Yuan Lee, Li-Ang |
關鍵字: | RANTES; adenotonsillectomy; basic fibroblast growth factor; children; granulocyte-macrophage colony-stimulating factor; interleukin; monocyte chemotactic protein; obesity; obstructive sleep apnea; platelet-derived growth factor | 公開日期: | 20-二月-2020 | 卷: | 9 | 期: | 2 | 來源出版物: | Journal of clinical medicine | 摘要: | Both obstructive sleep apnea (OSA) and obesity are major health issues that contribute to increased systemic inflammation in children. To date, adenotonsillectomy (AT) is still the first-line treatment for childhood OSA. However, the relationships among and predictive values of obesity, inflammation, and OSA severity have not been comprehensively investigated. This prospective study investigated body mass index (BMI), serum inflammatory markers, and OSA severity before and after AT in 60 pediatric patients with OSA. At baseline, differences in levels of interleukin-6, interleukin-9, basic fibroblast growth factor, platelet-derived growth factor-BB, as well as regulated on activation, normal T cell expressed and secreted (RANTES) were significant among the various weight status and OSA severity subgroups. After 3 months postoperatively, the differences in these inflammatory markers diminished along with a decrease in OSA severity while obesity persisted. The rate of surgical cure (defined as postoperative obstructive apnea-hypopnea index < 2.0 and obstructive apnea index < 1.0) was 62%. Multivariate analysis revealed that age, BMI z-score, granulocyte-macrophage colony-stimulating factor, monocyte chemotactic protein-1, and RANTES independently predicted surgical cure. Despite the significant reductions in inflammatory markers and OSA severity after AT, an inter-dependent relationship between obesity and OSA persisted. In addition to age and BMI, several inflammatory markers helped to precisely predict surgical cure. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/586672 | ISSN: | 2077-0383 | DOI: | 10.3390/jcm9020579 |
顯示於: | 醫學檢驗暨生物技術學系 |
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