Determination of synthetic cathinone α-pyrrolidinovalero-phenone and its metabolite in urine using solid-phase extraction and gas chromatography-mass spectrometry
Journal
Rapid communications in mass spectrometry : RCM
Journal Volume
34 Suppl 1
Journal Issue
S1
Date Issued
2020-04
Author(s)
Cheng, Kai-Wen
Hsieh, Chien-Ming
Chi, Pin-Chieh
Yang, Da-Peng
Chan, She-Hung
Chen, Ju-Yu
Abstract
The presence of α-pyrrolidinovalerophenone (α-PVP) and its metabolites in urine is evidence of the administration of α-PVP. A toxicological challenge is that the metabolites of α-PVP exhibit amphoteric properties, which make them unsuitable for detection using gas chromatography-mass spectrometry (GC/MS). In the study reported, proper derivatization and sample extraction were essential for improving the sensitivity for GC/MS analysis.
SDGs
Other Subjects
alkaloid; alpha-pyrrolidinovalerophenone; cathinone; designer drug; pyrrolidine derivative; human; limit of detection; mass fragmentography; metabolism; procedures; solid phase extraction; substance abuse; urine; Alkaloids; Designer Drugs; Gas Chromatography-Mass Spectrometry; Humans; Limit of Detection; Pyrrolidines; Solid Phase Extraction; Substance Abuse Detection
Type
journal article