https://scholars.lib.ntu.edu.tw/handle/123456789/586913| Title: | Determination of synthetic cathinone α-pyrrolidinovalero-phenone and its metabolite in urine using solid-phase extraction and gas chromatography-mass spectrometry | Authors: | Cheng, Kai-Wen Hsieh, Chien-Ming HUEI-WEN CHEN Chi, Pin-Chieh Yang, Da-Peng Chan, She-Hung Chen, Ju-Yu HSIAO-LIN HWA CHENG-CHUNG FANG TE-I WENG PAI-SHAN CHEN |
Issue Date: | Apr-2020 | Journal Volume: | 34 Suppl 1 | Journal Issue: | S1 | Source: | Rapid communications in mass spectrometry : RCM | Abstract: | The presence of α-pyrrolidinovalerophenone (α-PVP) and its metabolites in urine is evidence of the administration of α-PVP. A toxicological challenge is that the metabolites of α-PVP exhibit amphoteric properties, which make them unsuitable for detection using gas chromatography-mass spectrometry (GC/MS). In the study reported, proper derivatization and sample extraction were essential for improving the sensitivity for GC/MS analysis. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/586913 | ISSN: | 09514198 | DOI: | 10.1002/rcm.8579 | SDG/Keyword: | [SDGs]SDG3 alkaloid; alpha-pyrrolidinovalerophenone; cathinone; designer drug; pyrrolidine derivative; human; limit of detection; mass fragmentography; metabolism; procedures; solid phase extraction; substance abuse; urine; Alkaloids; Designer Drugs; Gas Chromatography-Mass Spectrometry; Humans; Limit of Detection; Pyrrolidines; Solid Phase Extraction; Substance Abuse Detection |
| Appears in Collections: | 法醫學科所 |
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