https://scholars.lib.ntu.edu.tw/handle/123456789/587231
標題: | Preoperative Serum Macrophage Migration Inhibitory Factor Level Correlates with Surgical Difficulty and Outcome in Patients with Autoimmune Thyroiditis | 作者: | Chong, Kian-Hwee MING-HSUN WU Chen, Chuang-Wei Hsieh, Tsung-Han Lai, Chieh-Wen |
關鍵字: | autoimmune thyroiditis; difficulty; outcome; serum biomarker; thyroidectomy;Autoimmune thyroiditis; Difficulty; Outcome; Serum biomarker; Thyroidectomy | 公開日期: | 7-九月-2021 | 卷: | 10 | 期: | 18 | 來源出版物: | Journal of clinical medicine | 摘要: | Surgical treatment for autoimmune thyroid disease is theoretically risky due to its chronic inflammatory status. This study aimed to investigate the correlation between preoperative serum migration inhibitory factor (MIF) levels and the difficulty of thyroidectomy in patients with autoimmune thyroiditis. Forty-four patients (average age: 54 years) were prospectively recruited: 30 with autoimmune thyroiditis and 14 with nodular goiter. Preoperative serum samples were collected to measure MIF levels. The difficulty of thyroidectomy was evaluated using a 20-point thyroidectomy difficulty scale (TDS) scoring system. The potential correlations between MIF levels and clinicopathological features as well as postoperative complications were analyzed. Preoperative serum thyroid-stimulating hormone (TSH), TSH receptor antibody, thyroid peroxidase antibodies levels, TDS score, and serum MIF levels were significantly higher in the autoimmune thyroiditis group than those in the goiter group. MIF levels were significantly associated with postoperative transient recurrent laryngeal nerve injury and hypoparathyroidism. MIF levels were positively correlated with TDS score, operation time, and blood loss in the autoimmune thyroiditis group. Increased preoperative serum MIF levels are associated with higher TDS scores, operation time, blood loss, and postoperative complications. Preoperative serum MIF level may be a useful predictor of difficult thyroidectomy and help surgeons provide better preoperative management. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/587231 | ISSN: | 2077-0383 | DOI: | 10.3390/jcm10184034 | SDG/關鍵字: | macrophage migration inhibition factor; thyroid peroxidase antibody; thyrotropin; thyrotropin receptor antibody; adult; antibody blood level; Article; autoimmune thyroiditis; clinical article; clinical feature; controlled study; female; hematoma; histopathology; human; human tissue; hypoparathyroidism; male; middle aged; nodular goiter; operation duration; operative blood loss; postoperative complication; preoperative period; protein blood level; recurrent laryngeal nerve injury; scoring system; thyroidectomy; Thyroidectomy Difficulty Scale; thyrotropin blood level |
顯示於: | 醫學系 |
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