https://scholars.lib.ntu.edu.tw/handle/123456789/587697
標題: | Mitochondrial DNA Variants in Patients with Liver Injury Due to Anti-Tuberculosis Drugs | 作者: | LI-NA LEE CHUN-TA HUANG Hsu, Chia-Lin Chang, Hsiu-Ching I-SHIOW JAN Liu, Jia-Luen JIN-CHUAN SHEU JANN-TAY WANG Liu, Wei-Lun Wu, Huei-Shu Chang, Ching-Nien JANN-YUAN WANG |
關鍵字: | DNA variants; Drug-induced liver injury; complex I; mitochondria; tuberculosis | 公開日期: | 13-八月-2019 | 卷: | 8 | 期: | 8 | 來源出版物: | Journal of clinical medicine | 摘要: | Hepatotoxicity is the most severe adverse effect of anti-tuberculosis therapy. Isoniazid's metabolite hydrazine is a mitochondrial complex II inhibitor. We hypothesized that mitochondrial DNA variants are risk factors for drug-induced liver injury (DILI) due to isoniazid, rifampicin or pyrazinamide. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/587697 | ISSN: | 2077-0383 | DOI: | 10.3390/jcm8081207 | SDG/關鍵字: | alanine aminotransferase; aspartate aminotransferase; bilirubin; bilirubin glucuronide; creatinine; ethambutol; genomic DNA; isoniazid; mitochondrial DNA; pyrazinamide; tuberculostatic agent; adult; Article; body mass; case control study; clinical article; controlled study; DNA extraction; DNA polymorphism; female; gene sequence; genome; genotype; human; male; middle aged; mitochondrial DNA depletion; next generation sequencing; prospective study; respiratory chain; toxic hepatitis |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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