https://scholars.lib.ntu.edu.tw/handle/123456789/587697
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | LI-NA LEE | en_US |
dc.contributor.author | CHUN-TA HUANG | en_US |
dc.contributor.author | Hsu, Chia-Lin | en_US |
dc.contributor.author | Chang, Hsiu-Ching | en_US |
dc.contributor.author | I-SHIOW JAN | en_US |
dc.contributor.author | Liu, Jia-Luen | en_US |
dc.contributor.author | JIN-CHUAN SHEU | en_US |
dc.contributor.author | JANN-TAY WANG | en_US |
dc.contributor.author | Liu, Wei-Lun | en_US |
dc.contributor.author | Wu, Huei-Shu | en_US |
dc.contributor.author | Chang, Ching-Nien | en_US |
dc.contributor.author | JANN-YUAN WANG | en_US |
dc.date.accessioned | 2021-11-23T08:33:58Z | - |
dc.date.available | 2021-11-23T08:33:58Z | - |
dc.date.issued | 2019-08-13 | - |
dc.identifier.issn | 2077-0383 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/587697 | - |
dc.description.abstract | Hepatotoxicity is the most severe adverse effect of anti-tuberculosis therapy. Isoniazid's metabolite hydrazine is a mitochondrial complex II inhibitor. We hypothesized that mitochondrial DNA variants are risk factors for drug-induced liver injury (DILI) due to isoniazid, rifampicin or pyrazinamide. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Journal of clinical medicine | en_US |
dc.subject | DNA variants; Drug-induced liver injury; complex I; mitochondria; tuberculosis | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | alanine aminotransferase; aspartate aminotransferase; bilirubin; bilirubin glucuronide; creatinine; ethambutol; genomic DNA; isoniazid; mitochondrial DNA; pyrazinamide; tuberculostatic agent; adult; Article; body mass; case control study; clinical article; controlled study; DNA extraction; DNA polymorphism; female; gene sequence; genome; genotype; human; male; middle aged; mitochondrial DNA depletion; next generation sequencing; prospective study; respiratory chain; toxic hepatitis | - |
dc.title | Mitochondrial DNA Variants in Patients with Liver Injury Due to Anti-Tuberculosis Drugs | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.3390/jcm8081207 | - |
dc.identifier.pmid | 31412578 | - |
dc.identifier.scopus | 2-s2.0-85097257644 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/85097257644 | - |
dc.relation.journalvolume | 8 | en_US |
dc.relation.journalissue | 8 | en_US |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Laboratory Medicine | - |
crisitem.author.dept | Laboratory Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Laboratory Medicine | - |
crisitem.author.dept | Laboratory Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Center for Infection Control | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine-NTUHHC | - |
crisitem.author.orcid | 0000-0002-7654-2450 | - |
crisitem.author.orcid | 0000-0002-5234-4986 | - |
crisitem.author.orcid | 0000-0002-7936-5306 | - |
crisitem.author.orcid | 0000-0002-2503-7139 | - |
crisitem.author.orcid | 0000-0002-0924-3469 | - |
crisitem.author.orcid | 0000-0003-3406-366X | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | NTU Hsin-Chu Hospital | - |
顯示於: | 醫學院附設醫院 (臺大醫院) |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。