https://scholars.lib.ntu.edu.tw/handle/123456789/587697
Title: | Mitochondrial DNA Variants in Patients with Liver Injury Due to Anti-Tuberculosis Drugs | Authors: | LI-NA LEE CHUN-TA HUANG Hsu, Chia-Lin Chang, Hsiu-Ching I-SHIOW JAN Liu, Jia-Luen JIN-CHUAN SHEU JANN-TAY WANG Liu, Wei-Lun Wu, Huei-Shu Chang, Ching-Nien JANN-YUAN WANG |
Keywords: | DNA variants; Drug-induced liver injury; complex I; mitochondria; tuberculosis | Issue Date: | 13-Aug-2019 | Journal Volume: | 8 | Journal Issue: | 8 | Source: | Journal of clinical medicine | Abstract: | Hepatotoxicity is the most severe adverse effect of anti-tuberculosis therapy. Isoniazid's metabolite hydrazine is a mitochondrial complex II inhibitor. We hypothesized that mitochondrial DNA variants are risk factors for drug-induced liver injury (DILI) due to isoniazid, rifampicin or pyrazinamide. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/587697 | ISSN: | 2077-0383 | DOI: | 10.3390/jcm8081207 | SDG/Keyword: | alanine aminotransferase; aspartate aminotransferase; bilirubin; bilirubin glucuronide; creatinine; ethambutol; genomic DNA; isoniazid; mitochondrial DNA; pyrazinamide; tuberculostatic agent; adult; Article; body mass; case control study; clinical article; controlled study; DNA extraction; DNA polymorphism; female; gene sequence; genome; genotype; human; male; middle aged; mitochondrial DNA depletion; next generation sequencing; prospective study; respiratory chain; toxic hepatitis |
Appears in Collections: | 醫學院附設醫院 (臺大醫院) |
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