https://scholars.lib.ntu.edu.tw/handle/123456789/588118
標題: | Serial Plasma Cell-Free Circulating Tumor DNA Tests Identify Genomic Alterations for Early Prediction of Osimertinib Treatment Outcome in EGFR T790M–Positive NSCLC | 作者: | BIN-CHI LIAO Hsu, Wei-Hsun JIH-HSIANG LEE CHING-YAO YANG TZU-HSIU TSAI WEI-YU LIAO CHAO-CHI HO CHIA-CHI LIN JIN-YUAN SHIH CHONG-JEN YU Soo, Ross A CHIH-HSIN YANG |
關鍵字: | EGFR mutations; Non–small cell lung cancer; Osimertinib; Outcome prediction; ctDNA | 公開日期: | 一月-2021 | 卷: | 2 | 期: | 1 | 來源出版物: | JTO clinical and research reports | 摘要: | Recent advances in the detection of genomic DNA from plasma samples allow us to follow tumor DNA shedding in plasma during systemic treatment. Osimertinib is the standard of care for patients with NSCLC with acquired EGFR T790M mutations. We assessed changes in serial plasma cell-free circulating tumor DNA (ctDNA) genomic alterations to predict osimertinib efficacy. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/588118 | ISSN: | 26663643 | DOI: | 10.1016/j.jtocrr.2020.100099 |
顯示於: | 醫學系 |
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