https://scholars.lib.ntu.edu.tw/handle/123456789/588273
Title: | Treatment of electronic cigarette or vaping product use-associated lung injury (EVALI) by corticosteroid and low-dose pirfenidone: Report of a case | Authors: | Wu, Chia-Hao Liao, Ting-Yu YUNG-HSUAN CHEN PING-HUNG KUO |
Keywords: | corticosteroid; e‐cigarette or vaping product use associated lung injury (EVALI); organizing pneumonia; pirfenidone;corticosteroid; e-cigarette or vaping product use associated lung injury (EVALI); organizing pneumonia; pirfenidone | Issue Date: | Oct-2021 | Journal Volume: | 9 | Journal Issue: | 10 | Source: | Respirology case reports | Abstract: | Electronic (e)-cigarette or vaping product use-associated lung injury (EVALI) is a novel and potentially lethal disease first reported in the United States. We report the case of a 56-year-old man who presented to our hospital with dyspnoea and cough lasting for 2 months after using an e-cigarette for approximately 50 puffs over 2 weeks. Physical examination revealed crackles in the left lower lung. High-resolution computed tomography (HRCT) showed consolidation and ground-glass opacities in both lungs. The baseline forced vital capacity (FVC) and diffusion capacity for carbon monoxide (DLCO) were 65.7% and 63.9% of the predicted, respectively. Lung biopsy revealed organizing pneumonia with focal fibrosis. In addition to prednisolone, he was treated with a low-dose pirfenidone (200 mg three times per day) due to the persistence of a mild cough, exertional dyspnoea and basal crackles after discharge. His symptoms and FVC significantly improved, but the recovery of the DLCO was slow. The follow-up HRCT demonstrated only minimal fibrotic changes. To our knowledge, this was the first reported case of EVALI successfully treated with a combination of corticosteroid and antifibrotic agents. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/588273 | ISSN: | 2051-3380 | DOI: | 10.1002/rcr2.845 | SDG/Keyword: | antifibrotic agent; azathioprine; corticosteroid; cyclophosphamide; methylprednisolone; mycophenolic acid; pirfenidone; prednisolone; adult; Article; blood pressure; breathing rate; case report; clinical article; computer assisted tomography; corticosteroid therapy; coughing; crackle; diffusing capacity for carbon monoxide; dyspnea; exertional dyspnea; forced expiratory volume; forced vital capacity; high resolution computer tomography; human; leukocyte count; low drug dose; lung biopsy; lung function test; male; middle aged; oxygen saturation; physical examination; vaping associated lung injury [SDGs]SDG3 |
Appears in Collections: | 醫學系 |
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