https://scholars.lib.ntu.edu.tw/handle/123456789/588522
標題: | Prevalence of Acute Kidney Injury and Prognostic Significance in Patients with Acute Myocarditis | 作者: | YA-WEN YANG Wu C.-H. Ko W.-J. VIN-CENT WU JIN-SHING CHEN NAI-KUAN CHOU HONG-SHIEE LAI |
公開日期: | 2012 | 卷: | 7 | 期: | 10 | 起(迄)頁: | e48055 | 來源出版物: | PLoS ONE | 摘要: | Objective: Myocarditis is an inflammation of the myocardium. The condition is commonly associated with rapid disease progression and often results in profound shock. Impaired renal function is the result of impairment in end-organ perfusion and is highly prevalent among critically ill patients. The aim of this study was to evaluate the incidence of acute kidney injury (AKI) and identify the relationship between AKI and the prognosis of patients with acute myocarditis. Design, Measurements and Main Results: This retrospective study reviewed the medical records of 101 patients suffering from acute myocarditis between 1996 and 2011. Sixty of these patients (59%) developed AKI within 48 hours of being hospitalized. AKI defined as AKIN stage 3 (p = 0.007) and SOFA score (p = 0.03) were identified as predictors of in-hospital mortality in multivariate analysis. The conditional effect plot of the estimated risk against SOFA score upon admission categorized according to the AKIN stages showed that the risk of in-hospital mortality was highest among patients in AKIN stage 3 with a high SOFA score. Conclusions: Among patients with acute myocarditis, AKI defined as AKIN stage 3 and elevated SOFA score were associated with unfavorable outcomes. AKIN classification is a simple, reproducible, and easily applied evaluation tool capable of providing objective information related to the clinical prognosis of patients with acute myocarditis. ? 2012 Yang et al. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84868129088&doi=10.1371%2fjournal.pone.0048055&partnerID=40&md5=494b1b1900f2b2f66624f1a86d9abef5 https://scholars.lib.ntu.edu.tw/handle/123456789/588522 |
ISSN: | 1932-6203 | DOI: | 10.1371/journal.pone.0048055 | SDG/關鍵字: | acute kidney failure; acute myocarditis; adult; cohort analysis; controlled study; disease association; disease classification; disease severity; female; human; length of stay; major clinical study; male; medical record review; mortality; myocarditis; outcome assessment; prevalence; prognosis; reproducibility; retrospective study; review; scoring system; Sequential Organ Failure Assessment score; Acute Disease; Acute Kidney Injury; Adult; Comorbidity; Female; Hospital Mortality; Humans; Logistic Models; Male; Middle Aged; Multivariate Analysis; Myocarditis; Prevalence; Prognosis; Retrospective Studies; Risk Factors; Taiwan; Time Factors; Young Adult |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。