|Title:||Effectiveness of the 10 cm2 Rivastigmine Patch in Taiwanese Patients with Mild-to-Moderate Alzheimer’s Dementia: A 48-Week Real-World Observational Study||Authors:||Chang C.-C.
|Keywords:||Alzheimer’s disease; Cognitive function; Rivastigmine patch||Issue Date:||2021||Journal Volume:||38||Journal Issue:||10||Start page/Pages:||5286-5301||Source:||Advances in Therapy||Abstract:||
Introduction: The current study aimed to provide data on the effectiveness of the 10 cm2 rivastigmine patch in patients with Alzheimer’s disease (AD) in a real-world setting in Taiwan. Methods: This was a 48-week, single-arm, open-label, observational, and post-marketing study conducted across seven centers in Taiwan between May 5, 2016 and July 10, 2017. Eligible patients (aged 55–95?years) treated with the 10?cm2rivastigmine patch were enrolled based on physicians’ judgment and according to the Taiwan reimbursement criteria of the drug. Data were prospectively collected at Week 0 (baseline), Week 24, and Week 48. The primary endpoint was the change in the cognitive assessment screening instrument (CASI) scores at Week 48 versus baseline. The changes from baseline in clinical dementia rating (CDR), mini-mental state examination (MMSE), and neuropsychiatric inventory (NPI) scores were evaluated, as were treatment persistence and the safety profile. Results: Of the 285 eligible patients [full analysis set (FAS)], 216 (75.8%) completed the study protocol while 180 (63.2%) persisted on the 10 cm2 rivastigmine patch for the full 48?weeks. At baseline, 89.8% of patients had a CDR score of 0.5 or 1, while the change in CDR score at Week 48 was not significant. In the FAS, both the CASI and MMSE scores had numerical improvement at Week 24 but declined by 2.1 and 0.4 points, respectively, at Week 48 (p?=?0.005 and p?=?0.022). The increment in NPI scores was not significant. The most common drug-related adverse events (AEs) were pruritus (11.2%), nausea (3.5%), rash (3.2%), and vomiting (2.8%). Conclusions: The use of the 10?cm2 rivastigmine patch in the mild stage of AD maintained cognitive function at Week 24 and neuropsychiatric function at Week 48. The treatment persistency and safety profile support the clinical tolerability of the rivastigmine patch in the management of mild-to-moderate AD in Taiwan. ? 2021, The Author(s).
|ISSN:||0741238X||DOI:||10.1007/s12325-021-01893-6||SDG/Keyword:||rivastigmine; cholinesterase inhibitor; rivastigmine; acute kidney failure; adult; aged; Alzheimer disease; apathy; Article; body weight disorder; cause of death; Clinical Dementia Rating; colon cancer; decreased appetite; delusion; depression; drug efficacy; drug safety; ear disease; erythema; falling; female; follow up; hallucination; heart arrest; heart disease; heart failure; heart infarction; hemophagocytic syndrome; human; infection; infestation; inner ear disease; kidney disease; kidney failure; liver cirrhosis; liver metastasis; lung metastasis; major clinical study; male; mental disease; Mini Mental State Examination; multiple organ failure; nausea; neurologic disease; neuropsychiatric inventory; observational study; pneumonia; prospective study; pruritus; rash; respiratory failure; septic shock; Taiwan; Taiwanese; treatment duration; urinary tract disease; urinary tract infection; vomiting; cognition; treatment outcome; Alzheimer Disease; Cholinesterase Inhibitors; Cognition; Humans; Rivastigmine; Treatment Outcome
|Appears in Collections:||醫學院附設醫院 (臺大醫院)|
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