https://scholars.lib.ntu.edu.tw/handle/123456789/588762
標題: | State of the Art in HIV Drug Resistance: Surveillance and Regional Gaps | 作者: | Boucher C.A. Bobkova M.R. CHIEN-CHING HUNG Kaiser R. Marcelin A.-G. Streinu-Cercel A. van Wyk J. Dorr P. Vandamme A.-M. |
公開日期: | 2018 | 卷: | 20 | 期: | 1 | 起(迄)頁: | 43-57 | 來源出版物: | AIDS reviews | 摘要: | This article is the second of a two-part review aiming to identify gaps in the knowledge and management of human immunodeficiency virus type 1 drug resistance (HIVDR) from global and regional perspectives. Here, we examine the policy and programmatic gaps in HIVDR surveillance, the affected populations and settings, and implications for clinical practice. The expert authorship of this review convened to identify gaps in HIVDR surveillance, with a particular focus on specific regional variations within and between Europe and Asia, to highlight directions for research and implementation. Further, evidence was gathered from a review of published studies, guidelines, and current practices. This review found that despite recent progress in the development, harmonization, and implementation of guidelines on HIVDR reporting and surveillance, programmatic, and policy gaps reflect the regional variability in HIV epidemics, clinical practice, and resources. The need for representative surveillance was identified as a key gap that has the potential to inform management policies. Monitoring must keep up with the evolution of transmission routes to adapt appropriately, and this will be further impacted by migration from areas with increasing levels of resistance. Analysis of the latest clinical data, regional practice, policy, and guidelines has identified a number of gaps in HIVDR population monitoring and surveillance. More efforts are needed to align surveillance platforms with harm reduction and patient education, particularly in vulnerable subgroups. Addressing these gaps will facilitate research into and progress in the management of HIV across a wide range of health-care settings. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85055077936&partnerID=40&md5=7c433fbcab85b82b975aded9be0ee943 https://scholars.lib.ntu.edu.tw/handle/123456789/588762 |
ISSN: | 1698-6997 | SDG/關鍵字: | antiretrovirus agent; antiviral resistance; drug effect; female; genetics; human; Human immunodeficiency virus 1; Human immunodeficiency virus infection; male; pathogenicity; Anti-Retroviral Agents; Drug Resistance, Viral; Female; HIV Infections; HIV-1; Humans; Male |
顯示於: | 醫學系 |
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