Clinical predictors of the leading pathogens in human immunodeficiency virus-infected adults with community-onset bacteremia in the emergency department: The importance of transmission routes
Journal
Journal of Microbiology, Immunology and Infection
Journal Volume
51
Journal Issue
3
Pages
392-400
Date Issued
2016
Author(s)
Abstract
Background/Purpose: To investigate the clinical characteristics and pathogens of community-onset bacteremia among human immunodeficiency virus (HIV)-infected adults as well as to establish the clinical predictors of the major microorganisms. Methods: An observational cohort study was conducted retrospectively between January 2007 and December 2012. Demographic characteristics and pathogens determined from chart records were analyzed. Results: Of the 121 eligible HIV adults with bacteremia, there was a male predominance (106 patients, 87.6%); elderly individuals (age ? 65 years) accounted for only 2.5% of the study population (3 patients). Of the total microorganisms isolated (n = 123), Staphylococcus aureus (55, 44.7%) and Salmonella enterica (17, 13.8%) were the common pathogens. In a multivariate analysis, the leading two significant predictors of S. aureus infection were infective endocarditis (odds ratio, 11.49; p = 0.001) and transmission risk with injection drug users (IDUs; odds ratio, 6.22; p = 0.001). In addition, transmission risk with men who have sex with men (MSM; odds ratio, 37.49; p = 0.001) was the leading clinical predictor of S. enterica infection. In further analyses, a strong linear-by-linear correlation between S. aureus infection and IDU (γ = 0.94, p = 0.02) as well as between S. enterica infection and MSM (γ = 0.96, p = 0.01) was evidenced. Conclusion: Focusing on the two key pathogens in HIV-infected adults with community-onset bacteremia, IDU was one of independent predictors associated with S. aureus infection, whereas MSM was the leading risk factor of S. enterica infection. Although the proposed predictive model of these pathogens has been not established, a scoring system involving the transmission risk of HIV may be of use for the early identification of these patients for clinicians. ? 2017
Subjects
bacteremia; human immunodeficiency virus; Salmonella enterica; Staphylococcus aureus
Other Subjects
adult; aged; Article; bacteremia; bacterial endocarditis; bacterium isolation; CD4 lymphocyte count; clinical feature; cohort analysis; emergency ward; female; human; Human immunodeficiency virus infected patient; Human immunodeficiency virus infection; infection risk; infectious agent; intravenous drug abuse; major clinical study; male; medical record review; men who have sex with men; multicenter study; nonhuman; observational study; retrospective study; Salmonella enterica; Staphylococcus aureus; Staphylococcus infection; typhoid fever; virus transmission; age; bacteremia; bacterial endocarditis; blood culture; community acquired infection; complication; endocarditis; hospital emergency service; Human immunodeficiency virus infection; microbiology; middle aged; mortality; multivariate analysis; pathogenicity; risk factor; salmonellosis; septic shock; severity of illness index; sex factor; Staphylococcus infection; Taiwan; transmission; virus load; Adult; Age Factors; Aged; Bacteremia; Blood Culture; CD4 Lymphocyte Count; Cohort Studies; Community-Acquired Infections; Emergency Service, Hospital; Endocarditis; Endocarditis, Bacterial; Female; HIV Infections; Humans; Male; Middle Aged; Multivariate Analysis; Retrospective Studies; Risk Factors; Salmonella enterica; Salmonella Infections; Severity of Illness Index; Sex Factors; Shock, Septic; Staphylococcal Infections; Staphylococcus aureus; Taiwan; Viral Load
Publisher
Elsevier Ltd
Type
journal article