https://scholars.lib.ntu.edu.tw/handle/123456789/588795
標題: | National trend and characteristics of acute hepatitis C among HIV-infected individuals: A matched case-Control Study-Taiwan, 2001-2014 | 作者: | Lo Y.-C. Tsai M.-S. HSIN-YUN SUN CHIEN-CHING HUNG Chuang J.-H. Meng Z. |
公開日期: | 2015 | 出版社: | Public Library of Science | 卷: | 10 | 期: | 10 | 起(迄)頁: | e0139687 | 來源出版物: | PLoS ONE | 摘要: | Background Hepatitis C virus (HCV) infection has been increasingly recognized among HIV-infected men who have sex with men (MSM) worldwide. We investigated the trend of and factors associated with acute hepatitis C (AHC) among HIV-infected individuals in Taiwan. Methods The National Disease Surveillance System collects characteristics of AHC, HIV, syphilis, and gonorrhea cases through mandatory reports and patient interviews. Reported AHC patients in 2014 were interviewed additionally on sexual and parenteral exposures. Information on HCV genotypes were collected from the largest medical center serving HIV-infected Taiwanese. We defined an HIV/AHC case as a documented negative HCV antibody test result followed within 12 months by a positive test in a previously reported HIV-infected individual. Each case was matched to two HIV-infected, non-AHC controls forage, age of HIV diagnosis, sex, transmission route, HIV diagnosis date, and county/city. Conditional logistic regression was used to identify associated characteristics. Results During 2001-2014, 93 of 6,624 AHC reports were HIV/AHC cases; the annual case count increased from one in 2009 to 34 in 2014. All were males (81 [87%] MSM) aged 21-49 years with AHC diagnosed 2-5,923 days after HIV diagnoses. Sixty-eight (73%) lived in the Taipei metropolitan area. Detected HCV genotypes were 2a (n = 6), 1b (n = 5), 1b + 2a (n = 1) and 2b (n = 1). Among 28 HIV/AHC patients interviewed in 2014,13 (46%) reported engaging in unprotected sex <3 months before AHC diagnosis. Seventy-nine HIV/AHC cases were matched to 158 controls. HIV/AHC was associated with recent syphilis (adjusted odds ratio [aOR], 10.9; 95% confidence interval [CI], 4.2-28.6) and last syphilis >6 months (aOR, 2.9; 95% CI, 1.2-6.9). Conclusions HIV/AHC cases continued to increase particularly among sexually active HIV-infected MSM with a syphilis diagnosis in northern Taiwan. We recommend surveillance of associated behavioral and virologic characteristics and HCV counseling and testing for HIV-infected men in Taiwan. ? 2015 Lo et al. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84947704690&doi=10.1371%2fjournal.pone.0139687&partnerID=40&md5=a8fe251c18b32f4d59c0eb233f2b8d9f https://scholars.lib.ntu.edu.tw/handle/123456789/588795 |
ISSN: | 1932-6203 | DOI: | 10.1371/journal.pone.0139687 | SDG/關鍵字: | acute hepatitis C; adult; Article; case control study; clinical feature; controlled study; disease association; geographic distribution; gonorrhea; human; Human immunodeficiency virus infected patient; Human immunodeficiency virus infection; major clinical study; male; men who have sex with men; seroconversion; syphilis; Taiwan; trend study; unprotected sex; viral genetics; virus load; virus transmission; comorbidity; health survey; hepatitis C; HIV Infections; incidence; male homosexuality; middle aged; prevalence; risk factor; unsafe sex; young adult; Adult; Case-Control Studies; Comorbidity; Hepatitis C; HIV Infections; Homosexuality, Male; Humans; Incidence; Male; Middle Aged; Population Surveillance; Prevalence; Risk Factors; Taiwan; Unsafe Sex; Young Adult |
顯示於: | 醫學系 |
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