https://scholars.lib.ntu.edu.tw/handle/123456789/588802
標題: | Detection of human parvovirus 4 viremia in the follow-up blood samples from seropositive individuals suggests the existence of persistent viral replication or reactivation of latent viral infection Emerging viruses | 作者: | Chen M.-Y. CHIEN-CHING HUNG Lee K.-L. |
公開日期: | 2015 | 出版社: | BioMed Central Ltd. | 卷: | 12 | 期: | 1 | 起(迄)頁: | 94 | 來源出版物: | Virology Journal | 摘要: | Background: The transmission routes for human parvovirus 4 (PARV4) infections in areas with high seroprevalence are not known. In the work described here, persistent PARV4 viral replication was investigated by conducting a longitudinal study. Methods: Ten healthcare workers each provided a blood sample at the beginning of the study (first sample) and 12 months later (second sample). The paired samples were tested for PARV4-positivity by immunoblotting analysis and nested polymerase chain reactions. Results: IgG antibodies against PARV4 were detected in six participants, three of whom also had IgM antibodies against PARV4. The immunoblotting results did not vary over time. PARV4 DNA was detected in the first blood sample from one participant who had IgG antibodies against PARV4 and in the second blood samples from 2 participants who had IgG and IgM antibodies against PARV4. Conclusions: Detection of PARV4 DNA in the second blood samples from two seropositive participants suggests the existence of persistent PARV4 replication or reactivation of inactive virus in the tissues. The finding of persistent or intermittent PARV4 replication in individuals with past infections provides an important clue toward unraveling the non-parenteral transmission routes of PARV4 infection in areas where the virus is endemic. ? 2015 Chen et al. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84932167226&doi=10.1186%2fs12985-015-0326-0&partnerID=40&md5=d8df618a2928143c4c27892d72b0508a https://scholars.lib.ntu.edu.tw/handle/123456789/588802 |
ISSN: | 1743-422X | DOI: | 10.1186/s12985-015-0326-0 | SDG/關鍵字: | immunoglobulin G antibody; immunoglobulin M antibody; virus DNA; immunoglobulin G; immunoglobulin M; virus antibody; adult; antibody detection; Article; blood sampling; clinical article; controlled study; endemic disease; female; follow up; health care personnel; human; Human parvovirus 4; Human parvovirus 4 viremia; immunoblotting; latent virus infection; longitudinal study; male; middle aged; Parechovirus; picornavirus infection; polymerase chain reaction; serodiagnosis; virus detection; virus reactivation; virus replication; virus transmission; young adult; blood; isolation and purification; Parvoviridae; parvovirus infection; physiology; viremia; virology; virus activation; virus replication; Human parvovirus 4; Parvovirus; Adult; Antibodies, Viral; Blood; DNA, Viral; Female; Health Personnel; Humans; Immunoglobulin G; Immunoglobulin M; Longitudinal Studies; Male; Parvoviridae Infections; Parvovirus; Viremia; Virus Activation; Virus Replication; Young Adult |
顯示於: | 醫學系 |
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