|Title:||Associated factors with syphilis among human immunodeficiency virus-infected men who have sex with men in Taiwan in the era of combination antiretroviral therapy||Authors:||Chang Y.-H.
|Issue Date:||2014||Publisher:||Elsevier Ltd||Journal Volume:||47||Journal Issue:||6||Start page/Pages:||533-541||Source:||Journal of Microbiology, Immunology and Infection||Abstract:||
Background/Purpose: Little is known about the factors associated with syphilis among human immunodeficiency virus (HIV)-infected men who have sex with men (MSM) with access to combination antiretroviral therapy (cART) in Taiwan, where MSM has re-emerged as the leading risk group for HIV transmission. Methods: From March to October 2011, MSM who regularly attended HIV clinics at a university hospital were invited to participate in the study. A structured questionnaire interview was conducted to collect information on sociodemographic characteristics, immunologic and virologic status, sexual partners and patterns of sexual behavior, and use of recreational drugs. Results: During the study period, 310 HIV-infected MSM with a mean age of 35.5 years were enrolled, of which 82.3% (. n=255) were sexually active and 37.4% (. n=116) used recreational drugs in the past 6 months. Syphilis was self-reported in 46.5% (. n=144) of the participants after HIV infection was diagnosed and 37.5% (112/299) had serologic evidence of syphilis within 1 year before enrollment. Multivariate logistic regression analysis limited to those who were receiving cART showed that higher CD4 counts [adjusted odds ratio (AOR): 1.17; 95% confidence interval (CI): 1.02-1.34], lower educational achievement (AOR: 1.95; 95% CI: 1.05-3.63), serosorting (AOR: 3.32; 95% CI: 1.04-10.63), and use of recreational drugs (AOR: 2.55; 95% CI: 1.26-5.13) were associated with syphilis. Conclusion: Improved immune status, lower educational achievement, serosorting, and use of recreational drugs were associated with syphilis among HIV-infected MSM who were receiving cART. These findings suggest that strengthening client-specific counseling is needed to reduce risks for syphilis among HIV-infected MSM in Taiwan. ? 2013, Taiwan Society of Microbiology.
|ISSN:||1684-1182||DOI:||10.1016/j.jmii.2013.11.003||SDG/Keyword:||antiretrovirus agent; recreational drug; adult; antiviral therapy; Article; CD4 lymphocyte count; combination antiretroviral therapy; condom use; controlled study; drug combination; high risk population; HIV serosorting; human; Human immunodeficiency virus infection; Human immunodeficiency virus prevalence; major clinical study; male; men who have sex with men; self report; sexual behavior; sexuality; structured questionnaire; syphilis; Coinfection; complication; cross-sectional study; highly active antiretroviral therapy; HIV Infections; male homosexuality; questionnaire; risk factor; syphilis; Taiwan; young adult; Adult; Antiretroviral Therapy, Highly Active; Coinfection; Cross-Sectional Studies; HIV Infections; Homosexuality, Male; Humans; Male; Risk Factors; Surveys and Questionnaires; Syphilis; Taiwan; Young Adult
|Appears in Collections:||醫學系|
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.