https://scholars.lib.ntu.edu.tw/handle/123456789/588833
標題: | Reduced bone mineral density among HIV-infected patients in Taiwan: Prevalence and associated factors | 作者: | Tsai M.-S. CHIEN-CHING HUNG Liu W.-C. Chen K.-L. Chen M.-Y. SZU-MIN HSIEH WANG-HUEI SHENG HSIN-YUN SUN TIFFANY TING-FANG SHIH |
公開日期: | 2014 | 出版社: | Elsevier | 卷: | 47 | 期: | 2 | 起(迄)頁: | 109-115 | 來源出版物: | Journal of Microbiology, Immunology and Infection | 摘要: | Background: Reduced bone mineral density (BMD) is an emerging threat to the successful long-term management of human immunodeficiency virus (HIV) infection among patients with access to combination antiretroviral therapy (cART). Data on the prevalence and associated factors of reduced BMD in Asian populations remain scarce. Methods: From March 2002 to April 2006, a cross-sectional survey was conducted among HIV-infected patients aged ? 20 years at the National Taiwan University Hospital. BMD of the lumbar spine was measured with the use of dual-energy X-ray absorptiometry. Osteopenia was defined as a BMD T-score between -1.0 and -2.5, and osteoporosis was defined as a BMD T-score ? -2.5. Linear and ordinal logistic regression analyses were performed. Results: Among 320 patients with a median age of 37.3 years, body mass index (BMI) of 21.4kg/m2 and 94.4% on cART, osteopenia and osteoporosis were diagnosed in 35.6% and 3.8%, respectively. On multivariate linear analysis, factors associated with reduced BMD were increasing age (p=0.006), longer duration on antiretroviral therapy (p=0.007), and a decreasing BMI (p=0.002). Using ordinal logistic regression, being underweight with a body mass index (BMI)<18.5kg/m2 was independently associated with reduced BMD (proportional odds ratio, 4.12; 95% confidence interval, 1.93-8.82). Conclusion: Reduced BMD was prevalent among HIV-infected Taiwanese adults on cART. Increased age, lower BMI, and exposure to antiretroviral therapy were significantly associated with decrease of BMD. ? 2012. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84897022814&doi=10.1016%2fj.jmii.2012.08.026&partnerID=40&md5=4b5837f10ba90a7e726c7b32f90e4f9c https://scholars.lib.ntu.edu.tw/handle/123456789/588833 |
ISSN: | 1684-1182 | DOI: | 10.1016/j.jmii.2012.08.026 | SDG/關鍵字: | nonnucleoside reverse transcriptase inhibitor; proteinase inhibitor; tenofovir; adult; age; antiviral therapy; article; body mass; bone density; cross-sectional study; disease association; dual energy X ray absorptiometry; female; human; Human immunodeficiency virus infected patient; Human immunodeficiency virus infection; Human immunodeficiency virus prevalence; major clinical study; male; middle aged; osteopenia; osteoporosis; sex difference; Taiwan; young adult; Antiretroviral therapy; Body mass index; Bone mineral density; HIV; Prevalence; Absorptiometry, Photon; Adult; Bone Density; Bone Diseases, Metabolic; Cross-Sectional Studies; Female; HIV Infections; Humans; Lumbosacral Region; Male; Middle Aged; Prevalence; Risk Factors; Spine; Taiwan |
顯示於: | 醫學系 |
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