https://scholars.lib.ntu.edu.tw/handle/123456789/588947
標題: | Molecular epidemiology of long-term colonization of Candida albicans strains from HIV-infected patients | 作者: | Li S.Y. Yang Y.L. Chen K.W. Cheng H.H. Chiou C.S. Wang T.H. Lauderdale T.L. CHIEN-CHING HUNG Lo H.J. |
公開日期: | 2006 | 卷: | 134 | 期: | 2 | 起(迄)頁: | 265-269 | 來源出版物: | Epidemiology and Infection | 摘要: | Twenty-one Candida albicans isolates from three HIV-infected patients were collected over a period of 3 years and characterized for fluconazole susceptibility, infectivity and genetic relatedness. Fluconazole resistance was found in five isolates, four exhibited dose-dependent susceptibility and the remainder were fully susceptible to this agent. Pulsed-field gel electrophoresis of SfiI restriction digests of the genomic DNA from the isolates revealed that isolates from the same swab specimen were identical despite differences in susceptibility to fluconazole and isolates recovered over time from the three patients retained clonally related DNA fingerprints within each patient. This small-scale study confirms the persistence of oral colonization of C. albicans strains in HIV-infected patients. Clinical data also suggests that the primary infecting strain may become a persistent colonist in the oral cavity once the immune function of the patient has been restored. ? 2005 Cambridge University Press. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-33244486781&doi=10.1017%2fS0950268805004905&partnerID=40&md5=f70a86cdab572609fdbca8fd91b494bb https://scholars.lib.ntu.edu.tw/handle/123456789/588947 |
ISSN: | 0950-2688 | DOI: | 10.1017/S0950268805004905 | SDG/關鍵字: | antiretrovirus agent; fluconazole; genomic DNA; nystatin; adult; antibiotic resistance; antibiotic sensitivity; article; case report; comorbidity; disease association; DNA fingerprinting; dose response; fungal colonization; fungal strain; fungus isolation; human; Human immunodeficiency virus; Human immunodeficiency virus infection; immune response; long term care; minimum inhibitory concentration; molecular epidemiology; pulsed field gel electrophoresis; thrush; Adult; Antifungal Agents; Candida albicans; Candidiasis, Oral; DNA Fingerprinting; Drug Resistance, Bacterial; Epidemiology, Molecular; Female; Fluconazole; HIV Infections; Humans; Immunocompromised Host; Male; Middle Aged |
顯示於: | 醫學系 |
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