https://scholars.lib.ntu.edu.tw/handle/123456789/589027
標題: | Bacteremia due to campylobacter species: High rate of resistance to macrolide and quinolone antibiotics | 作者: | Lu P.-L. PO-REN HSUEH CHIEN-CHING HUNG SHAN-CHWEN CHANG KWEN-TAY LUH Lee C.-Y. |
公開日期: | 2000 | 卷: | 99 | 期: | 8 | 起(迄)頁: | 612-617 | 來源出版物: | Journal of the Formosan Medical Association | 摘要: | Background and purpose: Although the rate of isolation of Campylobacter from stool specimens in Taiwan is similar to those in other developed countries, Campylobacter bacteremia has rarely been reported in Taiwan, and the patterns of antimicrobial susceptibility of blood isolates to various antimicrobial agents remain unknown in the Taiwanese population. The purpose of this study was to determine the clinical characteristics of patients with Campylobacter infection in a university hospital in Taiwan and the antimicrobial susceptibility patterns of the Campylobacter isolates. Methods: We retrospectively reviewed medical records of all patients with Campylobacter bacteremia treated in a university hospital between January 1991 and March 1999. Minimum inhibitory concentrations of 13 antimicrobial agents to 10 stored blood isolates were determined using the E-test. Results: Approximately half (52%) of the 21 patients had chronic liver disease and one-quarter had hepatobiliary or gastrointestinal malignancies. Thirteen (62%) patients had conditions that were associated with gastroenteritis. Other clinical manifestations associated with Campylobacter infection included cellulitis, perinatal sepsis, peritonitis, vascular catheter-related infection, and primary bacteremia. The duration of illness was generally short: approximately half (52%) of the 21 patients had fever lasting for only 1 day. Antimicrobial susceptibility testing of the 10 isolates revealed that most of the blood isolates were resistant to erythromycin and nalidixic acid (100% and 90%, respectively), while the rate of cross-resistance between erythromycin and azithromycin was 70%, and that between nalidixic acid and ciprofloxacin was 67%. Conclusions: Our observations suggest that Campylobacter bacteremia should be included in the differential diagnosis of patients with chronic liver disease or malignancies involving the hepatobiliary system or gastrointestinal tract who present with fever and gastroenteritis. Clinicians in Taiwan should be alert to the high rate of resistance of Campylobacter isolates to macrolide and quinolone antibiotics. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0033845084&partnerID=40&md5=adc665abb3d38bb1a5b8959cf736dd23 https://scholars.lib.ntu.edu.tw/handle/123456789/589027 |
ISSN: | 0929-6646 | SDG/關鍵字: | amoxicillin plus clavulanic acid; ampicillin; antibiotic agent; azithromycin; ceftriaxone; chloramphenicol; ciprofloxacin; clindamycin; cotrimoxazole; erythromycin; gentamicin; imipenem; nalidixic acid; tetracycline; adolescent; adult; aged; antibiotic resistance; article; bacteremia; bacterial peritonitis; bacterium isolation; Campylobacter; cellulitis; child; chronic liver disease; clinical article; clinical feature; cross resistance; female; fever; gastroenteritis; gastrointestinal disease; Gram negative infection; hepatobiliary disease; human; male; minimum inhibitory concentration; sepsis; Taiwan; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Anti-Infective Agents; Bacteremia; Campylobacter Infections; Child; Child, Preschool; Drug Resistance, Microbial; Female; Fluoroquinolones; Humans; Macrolides; Male; Middle Aged; Retrospective Studies |
顯示於: | 醫學系 |
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