https://scholars.lib.ntu.edu.tw/handle/123456789/589427
標題: | Association of amino-terminal pro-brain natriuretic peptide with metabolic syndrome | 作者: | WEN-YI LI Chiu F.-C. Chien Y.-F. JOU-WEI LIN HWANG, JUEY-JEN |
公開日期: | 2011 | 卷: | 50 | 期: | 11 | 起(迄)頁: | 1143-1147 | 來源出版物: | Internal Medicine | 摘要: | Objective This study evaluated the relationship between individual components in metabolic syndrome (MetS) and amino-terminal pro-brain natriuretic peptide (NT-proBNP). Methods A screening program for MetS in 2008 in Taiwan excluded subjects aged <30 years and pregnant women. Fasting glucose, insulin level, high-sensitivity C-reactive protein (hsCRP), and NT-proBNP were assessed. A propensity-score matching process was used to select subjects with and without MetS comparable in age, gender, body height, and serum creatinine levels. A multiple regression model was used to determine the association between individual components of MetS and NT-proBNP. Finally 270 subjects with MetS and another 270 matched subjects without MetS aged ^30 years were included. Results The subjects with MetS had higher uric acid and hsCRP, but not NT-proBNP. Multiple regression model showed that log (NT-proBNP) was positively associated with systolic blood pressure ((3=0.002 per mmHg, p=0.013), but negatively associated with body mass index ((5=-0.017 per kg/m2, p=0.018), triglyceride (P=-0.00048 per mg/dL, p=0.020) and insulin level (P=-0.005 per mU/L, p=0.005). Log (NT-proBNP) was neutral to waist circumference, fasting glucose, high-density lipoprotein cholesterol, and diastolic blood pressure. Conclusion MetS was not associated with serum NT-proBNP concentrations due to the contradictory effects of each component. ? 2011 The Japanese Society of Internal Medicine. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-79958043778&doi=10.2169%2finternalmedicine.50.4765&partnerID=40&md5=97142ab9d10ccd1e17ab215f9fecabbb https://scholars.lib.ntu.edu.tw/handle/123456789/589427 |
ISSN: | 0918-2918 | DOI: | 10.2169/internalmedicine.50.4765 | SDG/關鍵字: | amino terminal pro brain natriuretic peptide; C reactive protein; glucose; high density lipoprotein cholesterol; insulin; triacylglycerol; uric acid; adult; article; body mass; controlled study; diastolic blood pressure; disease association; female; glucose blood level; human; major clinical study; male; metabolic syndrome X; protein blood level; systolic blood pressure; waist circumference; Adult; Biological Markers; Blood Glucose; C-Reactive Protein; Case-Control Studies; Female; Humans; Insulin; Male; Metabolic Syndrome X; Middle Aged; Natriuretic Peptide, Brain; Peptide Fragments; Regression Analysis; Taiwan |
顯示於: | 醫學系 |
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