https://scholars.lib.ntu.edu.tw/handle/123456789/589566
標題: | Interplay of Prenatal and Postnatal Risk Factors in the Behavioral and Histological Features of a "Two-Hit" Non-Genetic Mouse Model of Schizophrenia | 作者: | Chang, Yi-Chun Li, Wai-Yu Lee, Lukas Jyuhn-Hsiarn LI-JEN LEE |
關鍵字: | dendritic structure; mPFC; risk factors; schizophrenia; stress-coping; ventral tegmental area (VTA) | 公開日期: | 12-十一月-2020 | 卷: | 21 | 期: | 22 | 來源出版物: | International journal of molecular sciences | 摘要: | Schizophrenia is a multifactorial developmental neuropsychiatric disorder. This study examined the interplay of maternal infection and postweaning social isolation, which are prenatal and postnatal risk factors, respectively. Pregnant mice received poly I:C or saline injection on gestation day 9 and the pups were weaned at postnatal day 28. After weaning, male offspring were randomly assigned into group-rearing and isolation-rearing groups. In their adulthood, we performed behavioral tests and characterized the histochemical features of their mesocorticolimbic structures. The sociability and anxiety levels were not affected by either manipulation, but synergistic effects of the two hits on stress-coping behavior was observed. Either of the single manipulations caused defects in sensorimotor gating, novel object recognition and spatial memory tests, but the combination of the two hits did not further exacerbate the disabilities. Prenatal infection increased the number of dopaminergic neurons in midbrain, whereas postweaning isolation decreased the GABAergic neurons in cortex. Single manipulation reduced the dendritic complexity and spine densities of neurons in the medial prefrontal cortex (mPFC) and dentate gyrus. Our results support the current perspective that disturbances in brain development during the prenatal or postnatal period influence the structure and function of the brain and together augment the susceptibility to mental disorders, such as schizophrenia. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/589566 | ISSN: | 16616596 | DOI: | 10.3390/ijms21228518 |
顯示於: | 解剖學暨細胞生物學科所 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。