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  1. NTU Scholars
  2. 醫學院
  3. 醫學院附設醫院 (臺大醫院)
Please use this identifier to cite or link to this item: https://scholars.lib.ntu.edu.tw/handle/123456789/590460
Title: Impact of MCA stenosis on the early outcome in acute ischemic stroke patients
Authors: JIANN-SHING JENG 
Jeng, Jiann-Shing; Hsieh, Fang-I; Yeh, Hsu-Ling; Chen, Wei-Hung; Chiu, Hou-Chang; Tang, Sung-Chun; Liu, Chung-Hsiang; Lin, Huey-Juan; Hsu, Shih-Pin; Lo, Yuk-Keung; Chan, Lung; Chen, Chih-Hung; Lin, Ruey-Tay; Chen, Yu-Wei; Lee, Jiunn-Tay; Yeh, Chung-Hsin; Lai, Ta-Chang; Sun, Yu; Sun, Mu-Chien; Chen, Po-Lin; Chiang, Tsuey-Ru; Lin, Shinn-Kuang; Chen, Chin-I; Bai, Chi-Huey ; Chen, Sien-Tsong; Chiou, Hung-Yi; Lien, Li-Ming; Hsu, Chung Y.; Sun, Ming-Hui
Yeh H.-L.
Chen W.-H.
Chiu H.-C.
SUNG-CHUN TANG 
Liu C.-H.
Lin H.-J.
Hsu S.-P.
Lo Y.-K.
Chan L.
Chen C.-H.
Lin R.-T.
Chen Y.-W.
Lee J.-T.
Yeh C.-H.
Sun M.-H.
Lai T.-C.
Sun Y.
Sun M.-C.
Chen P.-L.
Chiang T.-R.
Lin S.-K.
Yip B.-S.
Chen C.-I.
Bai C.-H.
Chen S.-T.
Chiou H.-Y.
Lien L.-M.
Hsu C.Y.
Issue Date: 2017
Journal Volume: 12
Journal Issue: 4
Start page/Pages: e0175434
Source: PLoS ONE
Abstract: 
Background: Asians have higher frequency of intracranial arterial stenosis. The present study aimed to compare the clinical features and outcomes of ischemic stroke patients with and without middle cerebral artery (MCA) stenosis, assessed by transcranial sonography (TCS), based on the Taiwan Stroke Registry (TSR). Methods: Patients with acute ischemic stroke or transient ischemic attack registered in the TSR, and received both carotid duplex and TCS assessment were categorized into those with stenosis (?50%) and without (<50%) in the extracranial internal carotid artery (ICA) and MCA, respectively. Logistic regression analysis, Kaplan-Meier method and Cox proportional hazard model were applied to assess relevant variables between groups. Results: Of 6003 patients, 23.3% had MCA stenosis, 10.1% ICA stenosis, and 3.9% both MCA and ICA stenosis. Patients with MCA stenosis had greater initial NIHSS, higher likelihood of stroke-in-evolution, and more severe disability than those without (all p<0.001). Patients with MCA stenosis had higher prevalence of hypertension, diabetes and hypercholesterol-emia. Patients with combined MCA and extracranial ICA stenosis had even higher NIHSS, worse functional outcome, higher risk of stroke recurrence or death (hazard ratio, 2.204; 95% confidence intervals, 1.440-3.374; p<0.001) at 3 months after stroke than those without MCA stenosis. Conclusions: In conclusion, MCA stenosis was more prevalent than extracranial ICA stenosis in ischemic stroke patients in Taiwan. Patients with MCA stenosis, especially combined extracranial ICA stenosis, had more severe neurological deficit and worse outcome. ? 2017 Jeng et al.This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
URI: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85017187063&doi=10.1371%2fjournal.pone.0175434&partnerID=40&md5=51668a57ac8a734f5f2c06aac1d4cc48
https://scholars.lib.ntu.edu.tw/handle/123456789/590460
ISSN: 19326203
DOI: 10.1371/journal.pone.0175434
SDG/Keyword: aged; Article; brain ischemia; clinical feature; controlled study; diabetes mellitus; disability; disease severity; echography; female; follow up; human; hypercholesterolemia; hypertension; hypertriglyceridemia; internal carotid artery occlusion; ischemic heart disease; major clinical study; male; middle cerebral artery occlusion; outcome assessment; prevalence; recurrence risk; risk factor; Taiwan; transcranial sonography; cerebrovascular accident; middle aged; middle cerebral artery; pathology; pathophysiology; stenosis, occlusion and obstruction; Aged; Constriction, Pathologic; Female; Humans; Male; Middle Aged; Middle Cerebral Artery; Stroke
[SDGs]SDG3
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