https://scholars.lib.ntu.edu.tw/handle/123456789/590484
標題: | Effect of mannitol on cerebrovascular pressure reactivity in patients with intracranial hypertension | 作者: | SUNG-CHUN TANG Lin R.-J. Shieh J.-S. Wu A.-Y. DAR-MING LAI Huang S.-J. JIANN-SHING JENG |
關鍵字: | Cerebral perfusion pressure;Cerebrovascular pressure reactivity;Intracranial hypertension;Mannitol | 公開日期: | 2015 | 卷: | 114 | 期: | 9 | 起(迄)頁: | 842-848 | 來源出版物: | Journal of the Formosan Medical Association | 摘要: | Background/Purpose: Mannitol is commonly used in patients with increased intracranial pressure (ICP), but its effect on cerebrovascular pressure reactivity (CVPR) is uncertain. We analyzed the changes of pressure reactivity index (PRx) during the course of mannitol treatment. Methods: Twenty-one patients who received mannitol treatment for increased ICP were recruited prospectively. Continuous waveforms of arterial blood pressure (ABP) and ICP were collected simultaneously for 60 minutes (10 minutes at baseline and 50 minutes since mannitol administration) during 37 events of mannitol treatment. The correlation coefficients between the mean ABP and ICP were averaged every 10 minutes and labeled as the PRx. The linear correlation of six time points of PRx in each event was calculated to represent the trend of CVPR changes. The negative slope of correlation was defined as improvement in CVPR under mannitol treatment and vice versa. Results: At baseline, the average of ICP was 26.0 ± 9.1 mmHg and the values of PRx were significantly correlated with ICP (p = 0.0044, r = 0.46). After mannitol administration, the average of ICP decreased significantly to 21.2 ± 11.1 mmHg (p = 0.036), and CVPR improved in 59.4 % of all events. Further analysis showed that low baseline cerebral perfusion pressure was the only hemodynamic parameter significant association with the improvement of CVPR after mannitol treatment (p = 0.039). Conclusion: Despite lowering ICP, mannitol may have diverse effects on CVPR in patients with intracranial hypertension. Our study suggests that mannitol infusion may have a beneficial effect on CVPR, particularly in those with a low cerebral perfusion pressure at baseline. © 2013. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84940447089&doi=10.1016%2fj.jfma.2013.09.002&partnerID=40&md5=324ac5d22700769ffed2a0c0e26dfa5d https://scholars.lib.ntu.edu.tw/handle/123456789/590484 |
ISSN: | 9296646 | DOI: | 10.1016/j.jfma.2013.09.002 |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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