Proteinuria independently predicts unfavorable outcome of ischemic stroke patients receiving intravenous thrombolysis
Journal
PLoS ONE
Journal Volume
8
Journal Issue
11
Pages
e80527
Date Issued
2013
Author(s)
Li C.-H.
Hsiao Y.-J.
Chen Y.-W.
Abstract
Background and Purpose: Patients with low estimated glomerular filtration rate (eGFR) and proteinuria may be at increased risk for stroke. This study investigated whether low eGFR and proteinuria are outcome predictors in stroke patients treated with intravenous thrombolysis. Methods: We studied 432 consecutive stroke patients who received thrombolysis from January 2006 to December 2012, in Taiwan. Unfavorable outcome was defined as modified Rankin scale ?2 at 3 months after stroke. Proteinuria was classified as negative or trace, mild, and moderate to severe. Using logistic regression analysis, we identified independent factors for unfavorable outcome after thrombolysis. Results: Of all patients, 32.7% had proteinuria. Patients with proteinuria were older, had higher frequencies of diabetes mellitus, hyperlipidemia, atrial fibrillation, lower eGFR, and greater severity of stroke upon admission than those without proteinuria. Proteinuria, not low eGFR, was an independent predictor for unfavorable outcome for stroke (OR = 2.00 for mild proteinuria, p = 0.035; OR = 2.54 for moderate to severe proteinuria, p = 0.035). However, no clear relationship was found between proteinuria and symptomatic hemorrhage after thrombolysis. Conclusions: Proteinuria is an independent predictor of unfavorable outcome for acute ischemic stroke in patients treated with intravenous thrombolysis, indicating the crucial role of chronic kidney disease on the effectiveness of thrombolysis. ? 2013 Chen et al.
SDGs
Other Subjects
Aged; Brain Ischemia; Female; Humans; Male; Middle Aged; Proteinuria; Stroke; Thrombolytic Therapy
Type
journal article
File(s)![Thumbnail Image]()
Loading...
Name
Proteinuria-independently-predicts-unfavorable-outcome-of-ischemic-stroke-patients-receiving-intravenous-thrombolysisPLoS-ONE.pdf
Size
148.76 KB
Format
Adobe PDF
Checksum
(MD5):51d7cafc0f27763f8a243a143869e0cd