https://scholars.lib.ntu.edu.tw/handle/123456789/590507
標題: | Proteinuria independently predicts unfavorable outcome of ischemic stroke patients receiving intravenous thrombolysis | 作者: | CHIH-HAO CHEN SUNG-CHUN TANG LI-KAI TSAI SHIN-JOE YEH KAI-HSIANG CHEN Li C.-H. Hsiao Y.-J. Chen Y.-W. Bak-Sau Yip JIANN-SHING JENG |
公開日期: | 2013 | 卷: | 8 | 期: | 11 | 起(迄)頁: | e80527 | 來源出版物: | PLoS ONE | 摘要: | Background and Purpose: Patients with low estimated glomerular filtration rate (eGFR) and proteinuria may be at increased risk for stroke. This study investigated whether low eGFR and proteinuria are outcome predictors in stroke patients treated with intravenous thrombolysis. Methods: We studied 432 consecutive stroke patients who received thrombolysis from January 2006 to December 2012, in Taiwan. Unfavorable outcome was defined as modified Rankin scale ?2 at 3 months after stroke. Proteinuria was classified as negative or trace, mild, and moderate to severe. Using logistic regression analysis, we identified independent factors for unfavorable outcome after thrombolysis. Results: Of all patients, 32.7% had proteinuria. Patients with proteinuria were older, had higher frequencies of diabetes mellitus, hyperlipidemia, atrial fibrillation, lower eGFR, and greater severity of stroke upon admission than those without proteinuria. Proteinuria, not low eGFR, was an independent predictor for unfavorable outcome for stroke (OR = 2.00 for mild proteinuria, p = 0.035; OR = 2.54 for moderate to severe proteinuria, p = 0.035). However, no clear relationship was found between proteinuria and symptomatic hemorrhage after thrombolysis. Conclusions: Proteinuria is an independent predictor of unfavorable outcome for acute ischemic stroke in patients treated with intravenous thrombolysis, indicating the crucial role of chronic kidney disease on the effectiveness of thrombolysis. ? 2013 Chen et al. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84894249670&doi=10.1371%2fjournal.pone.0080527&partnerID=40&md5=96a15a6d50b899872fe4fd782f162d43 https://scholars.lib.ntu.edu.tw/handle/123456789/590507 |
ISSN: | 19326203 | DOI: | 10.1371/journal.pone.0080527 | SDG/關鍵字: | Aged; Brain Ischemia; Female; Humans; Male; Middle Aged; Proteinuria; Stroke; Thrombolytic Therapy |
顯示於: | 醫學院附設醫院 (臺大醫院) |
檔案 | 描述 | 大小 | 格式 | |
---|---|---|---|---|
Proteinuria-independently-predicts-unfavorable-outcome-of-ischemic-stroke-patients-receiving-intravenous-thrombolysisPLoS-ONE.pdf | 148.76 kB | Adobe PDF | 檢視/開啟 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。