https://scholars.lib.ntu.edu.tw/handle/123456789/590510
標題: | Pre-ICH warfarin use, not antiplatelets, increased case fatality in spontaneous ICH patients | 作者: | Chen Y.-W. SUNG-CHUN TANG LI-KAI TSAI SHIN-JOE YEH Chiou H.-Y. Yip P.-K. JIANN-SHING JENG |
公開日期: | 八月-2013 | 卷: | 20 | 期: | 8 | 起(迄)頁: | 1128 | 來源出版物: | European Journal of Neurology | 摘要: | Background and purpose: Anticoagulant and antiplatelets for prevention of ischaemic stroke and cardiovascular diseases may increase the risk of intracerebral hemorrhage (ICH). This study aimed to investigate the influence of pre-ICH use of anticoagulant and antiplatelets on ICH patients. Methods: Consecutive patients with acute spontaneous ICH registered in a single-center stroke registry during 2001 to 2010 were analyzed and categorized according to their pre-ICH use of warfarin (Group I), antiplatelets (Group II), or neither (Group III). Survival analysis and the Cox proportional hazard model were used to compare between the three groups and the predictors. Results: Of 2021 ICH patients (male, 63.3%; mean age, 62.6?±?14.4?years) included, there were 94 (4.7%) in Group I, 232 (11.4%) in Group II, and 1695 (83.9%) in Group III. Warfarin users had larger hematoma volume, more intraventricular extension, higher frequencies of lobar ICH, and higher case fatality than non-warfarin users (Groups II and III). The Cox proportional hazard model showed increased 6-month case fatality in pre-ICH warfarin users (adjusted hazard ratio?2.75, 95% confidence interval?2.04-3.72, P?0.001), but not in pre-ICH antiplatelet users (adjusted hazard ratio?0.95, 95% confidence interval?0.72-1.26). Conclusions: Intracerebral hemorrhage patients with prior warfarin use, but not antiplatelet use, had significantly higher case fatality at 6?months. ? 2012 The Author(s) European Journal of Neurology ? 2012 EFNS. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84880109055&doi=10.1111%2fj.1468-1331.2012.03847.x&partnerID=40&md5=13c3c047fae79abbbca2fbdbac84f4db https://scholars.lib.ntu.edu.tw/handle/123456789/590510 |
ISSN: | 13515101 | DOI: | 10.1111/j.1468-1331.2012.03847.x | SDG/關鍵字: | anticoagulant agent; antithrombocytic agent; warfarin; adult; article; brain hemorrhage; fatality; female; follow up; hematoma; human; major clinical study; male; mortality; priority journal; anticoagulants; antiplatelet; cerebral hemorrhage; warfarin; Adult; Aged; Aged, 80 and over; Anticoagulants; Area Under Curve; Cerebral Hemorrhage; Female; Glasgow Coma Scale; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Proportional Hazards Models; Registries; ROC Curve; Stroke; Survival Analysis; Taiwan; Warfarin |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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