https://scholars.lib.ntu.edu.tw/handle/123456789/590664
標題: | VS-5584, a PI3K/mTOR dual inhibitor, exerts antitumor effects on neuroblastomas in vitro and in vivo | 作者: | Chen, Yun Tsai, Huang-Wen Tsai, Ya-Hui SHENG-HONG TSENG |
關鍵字: | Antitumor effects; Neuroblastoma; PI3K/mTOR dual inhibitor; VS-5584 | 公開日期: | 八月-2021 | 卷: | 56 | 期: | 8 | 來源出版物: | Journal of pediatric surgery | 摘要: | The phosphatidylinositol-3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway is closely related to oncogenesis. PI3K/mTOR inhibitors are considered capable of counteracting the feedback mechanisms within the pathway. In this study, we investigated the antitumor effects of VS-5584, an orally administered PI3K/mTOR dual inhibitor, on neuroblastomas. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/590664 | ISSN: | 00223468 | DOI: | 10.1016/j.jpedsurg.2020.10.033 |
顯示於: | 醫學系 |
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