|Title:||Role of autophagy-related protein in the prognosis of combined hepatocellular carcinoma and cholangiocarcinoma after surgical resection||Authors:||Perng D.-S.
|Keywords:||Autophagy; Combined hepatocellular carcinoma and cholangiocarcinoma; LC3; Predictive factors; Prognosis||Issue Date:||2021||Publisher:||BioMed Central Ltd||Journal Volume:||21||Journal Issue:||1||Source:||BMC Cancer||Abstract:||
Background: Autophagy-related proteins may predict postresection overall survival (OS) and disease-free survival (DFS) in patients with combined hepatocellular carcinoma and cholangiocarcinoma (cHCC-CC). Methods: We prospectively investigated how these proteins affect clinical prognosis in 40 patients who underwent hepatectomy for cHCC-CC from 2011 to 2019 at a Taiwanese hospital. Levels of autophagy-related proteins, namely LC3, Beclin-1, and p62, were immunohistochemically assessed in patient tumor and non-tumor tissues. Results: We noted that LC3 expression was significantly correlated with mild clinicopathological characteristics, including macrovascular invasion, lymph node metastasis, American Joint Committee on Cancer and Barcelona Clinic Liver Cancer stages, recurrence, and mortality. Ten patient showed tumor recurrence, and 15 patients died. Postresection 5-year OS and DFS rates were 43.7 and 57.4%, respectively. Cox regression analysis showed that high intratumoral LC3 expression was significantly associated with improved OS [hazard ratio (HR; 95% confidence interval (CI)): (1.68–26.9), p = 0.007], but multiple tumors and microvascular invasion was significantly correlated with poor OS [HR (95% CI): 0.03 (0.01–0.34), p = 0.004, and 0.07 (0.01–0.46), p = 0.006, respectively]. Furthermore, high LC3 expression and cirrhosis had improved DFS [HR (95% CI): 51.3 (2.85–922), p = 0.008, and 17.9 (1.05–306), p = 0.046, respectively]. The 5-year OS and DFS rates were respectively 61.2 and 74.6% in high LC3 expression patients and 0 and 0% in those with low LC3 expression. Conclusion: High LC3 expression in tumors is significantly associated with mild clinicopathological characteristics and favorable clinical prognosis in patients with cHCC-CC after resection. ? 2021, The Author(s).
|ISSN:||1471-2407||DOI:||10.1186/s12885-021-08553-6||SDG/Keyword:||autophagy related protein; beclin 1; microtubule associated protein 1; sequestosome 1; autophagy related protein; adult; Article; bile duct carcinoma; cancer prognosis; cancer recurrence; cancer staging; cancer surgery; Child Pugh score; clinical article; cohort analysis; computer assisted tomography; disease free survival; distant metastasis; female; follow up; human; human tissue; immunohistochemistry; incidence; liver cell carcinoma; liver cirrhosis; liver resection; lymph node metastasis; male; middle aged; mortality; nuclear magnetic resonance imaging; overall survival; prospective study; protein expression; bile duct carcinoma; liver cell carcinoma; liver tumor; metabolism; pathology; prognosis; Autophagy-Related Proteins; Carcinoma, Hepatocellular; Cholangiocarcinoma; Female; Humans; Liver Neoplasms; Male; Middle Aged; Prognosis; Prospective Studies
|Appears in Collections:||醫學系|
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