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  1. NTU Scholars
  2. 醫學院
  3. 醫學系
Please use this identifier to cite or link to this item: https://scholars.lib.ntu.edu.tw/handle/123456789/591818
Title: Role of autophagy-related protein in the prognosis of combined hepatocellular carcinoma and cholangiocarcinoma after surgical resection
Authors: Perng D.-S.
Hung C.-M.
Lin H.-Y.
Morgan P.
Hsu Y.-C.
Wu T.-C.
Hsieh P.-M.
Yeh J.-H.
Hsiao P.
CHIH-YUAN LEE 
Li Y.-C.
Wang Y.-C.
Chen Y.-S.
Lin C.-W.
Keywords: Autophagy; Combined hepatocellular carcinoma and cholangiocarcinoma; LC3; Predictive factors; Prognosis
Issue Date: 2021
Publisher: BioMed Central Ltd
Journal Volume: 21
Journal Issue: 1
Source: BMC Cancer
Abstract: 
Background: Autophagy-related proteins may predict postresection overall survival (OS) and disease-free survival (DFS) in patients with combined hepatocellular carcinoma and cholangiocarcinoma (cHCC-CC). Methods: We prospectively investigated how these proteins affect clinical prognosis in 40 patients who underwent hepatectomy for cHCC-CC from 2011 to 2019 at a Taiwanese hospital. Levels of autophagy-related proteins, namely LC3, Beclin-1, and p62, were immunohistochemically assessed in patient tumor and non-tumor tissues. Results: We noted that LC3 expression was significantly correlated with mild clinicopathological characteristics, including macrovascular invasion, lymph node metastasis, American Joint Committee on Cancer and Barcelona Clinic Liver Cancer stages, recurrence, and mortality. Ten patient showed tumor recurrence, and 15 patients died. Postresection 5-year OS and DFS rates were 43.7 and 57.4%, respectively. Cox regression analysis showed that high intratumoral LC3 expression was significantly associated with improved OS [hazard ratio (HR; 95% confidence interval (CI)): (1.68–26.9), p = 0.007], but multiple tumors and microvascular invasion was significantly correlated with poor OS [HR (95% CI): 0.03 (0.01–0.34), p = 0.004, and 0.07 (0.01–0.46), p = 0.006, respectively]. Furthermore, high LC3 expression and cirrhosis had improved DFS [HR (95% CI): 51.3 (2.85–922), p = 0.008, and 17.9 (1.05–306), p = 0.046, respectively]. The 5-year OS and DFS rates were respectively 61.2 and 74.6% in high LC3 expression patients and 0 and 0% in those with low LC3 expression. Conclusion: High LC3 expression in tumors is significantly associated with mild clinicopathological characteristics and favorable clinical prognosis in patients with cHCC-CC after resection. ? 2021, The Author(s).
URI: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110262671&doi=10.1186%2fs12885-021-08553-6&partnerID=40&md5=79121a3fb1cc8e6261f9c3c0c42ab43b
https://scholars.lib.ntu.edu.tw/handle/123456789/591818
ISSN: 1471-2407
DOI: 10.1186/s12885-021-08553-6
SDG/Keyword: autophagy related protein; beclin 1; microtubule associated protein 1; sequestosome 1; autophagy related protein; adult; Article; bile duct carcinoma; cancer prognosis; cancer recurrence; cancer staging; cancer surgery; Child Pugh score; clinical article; cohort analysis; computer assisted tomography; disease free survival; distant metastasis; female; follow up; human; human tissue; immunohistochemistry; incidence; liver cell carcinoma; liver cirrhosis; liver resection; lymph node metastasis; male; middle aged; mortality; nuclear magnetic resonance imaging; overall survival; prospective study; protein expression; bile duct carcinoma; liver cell carcinoma; liver tumor; metabolism; pathology; prognosis; Autophagy-Related Proteins; Carcinoma, Hepatocellular; Cholangiocarcinoma; Female; Humans; Liver Neoplasms; Male; Middle Aged; Prognosis; Prospective Studies
[SDGs]SDG3
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臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

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