https://scholars.lib.ntu.edu.tw/handle/123456789/591887
標題: | Effects of Protein Supplementation Combined with Exercise Training on Muscle Mass and Function in Older Adults with Lower-Extremity Osteoarthritis: A Systematic Review and Meta-Analysis of Randomized Trials | 作者: | Liao, Chun-De YEN-TZU WU Tsauo, Jau-Yih PEY-RONG CHEN YU-KANG TU Chen, Hung-Chou Liou, Tsan-Hon |
關鍵字: | arthroplasty; exercise training; muscle mass; osteoarthritis; physical function; protein supplement; sarcopenia;Arthroplasty; Exercise training; Muscle mass; Osteoarthritis; Physical function; Protein supplement; Sarcopenia | 公開日期: | 12-八月-2020 | 出版社: | MDPI | 卷: | 12 | 期: | 8 | 來源出版物: | Nutrients | 摘要: | Aging and osteoarthritis (OA) are associated with a high risk of muscle mass loss, which can lead to physical disability. This study investigated the effectiveness of protein supplementation combined with exercise training (PS + ET) in improving muscle mass and functional outcomes in older adults with lower-limb OA. A comprehensive search of online databases was performed to identify randomized controlled trials (RCTs) on the effectiveness of PS + ET in older adults with hip or knee OA. Meta-analysis and risk of bias assessment of the included RCTs were conducted. Six RCTs were included in this systemic review; they had a median (range/total) Physiotherapy Evidence Database (PEDro) score of 7 (6-9) out of 10, respectively. Five RCTs that enrolled patients who underwent total joint replacement were included in this meta-analysis. The PS + ET group exhibited significant improvements in muscle mass (standard mean difference [SMD] = 1.13, p < 0.00001), pain (SMD = 1.36, p < 0.00001), and muscle strength (SMD = 0.44, p = 0.04). Our findings suggest that PS + ET improves muscle mass, muscle strength, and functional outcomes and reduces pain in older adults with lower-limb OA, particularly in those who have undergone total joint replacement. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/591887 | ISSN: | 2072-6643 | DOI: | 10.3390/nu12082422 | SDG/關鍵字: | C reactive protein; interleukin 6; tumor necrosis factor; body mass; chair rise performance; diet supplementation; exercise; exercise intensity; follow up; Harris hip score; hospital discharge; human; Knee Injury and Osteoarthritis Outcome Score; meta analysis; muscle function; muscle mass; muscle strength; myalgia; obesity; osteoarthritis; outcome assessment; pain assessment; patient-reported outcome; physical activity; physical mobility; physiotherapy; protein diet; randomized controlled trial (topic); resistance training; Review; sarcopenia; Short Form 36; six minute walk test; stair climbing; systematic review; timed up and go test; total arthroplasty; total hip replacement; treatment outcome; walking speed; administration and dosage; aged; complication; dietary supplement; drug effect; exercise; female; kinesiotherapy; male; muscle atrophy; osteoarthritis; pathophysiology; physiology; procedures; protein intake; very elderly; Aged; Aged, 80 and over; Dietary Proteins; Dietary Supplements; Exercise; Exercise Therapy; Female; Humans; Male; Muscle Strength; Muscular Atrophy; Osteoarthritis; Physical Functional Performance; Randomized Controlled Trials as Topic; Treatment Outcome |
顯示於: | 物理治療學系所 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。