https://scholars.lib.ntu.edu.tw/handle/123456789/592047
標題: | Wound Healing in Streptozotocin-Induced Diabetic Rats Using Atmospheric-Pressure Argon Plasma Jet | 作者: | Cheng K.-Y. Lin Z.-H. Cheng Y.-P. HSIEN-YI CHIU Yeh N.-L. Wu T.-K. Wu J.-S. |
公開日期: | 2018 | 出版社: | Nature Publishing Group | 卷: | 8 | 期: | 1 | 來源出版物: | Scientific Reports | 摘要: | In this study, we used an argon-based round atmospheric-pressure plasma jet (APPJ) for enhancing wound healing in streptozotocin (STZ) induced diabetic rats. The APPJ was characterized by optical emission spectroscopy. We induced Type 1 and Type 2 diabetes in rats with different amounts of STZ combined with normal and high-fat diets, respectively. The wound area ratio of all the plasma-treated normal and diabetic groups was greatly reduced (up to 30%) compared with that of the untreated groups during healing. Histological analysis revealed faster re-epithelialization, collagen deposition, less inflammation, and a complete skin structure in the plasma-treated groups was found as compared with the untreated control groups. In addition, the new blood vessels of plasma-treated tissues decreased more than untreated tissues in the middle (Day 14) and late (Day 21) stages of wound healing. The plasma-treated wounds demonstrated more transforming growth factor beta (TGF-β) expression in the early stage (Day 7), whereas they decreased in the middle and late stages of wound healing. The levels of superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) increased after plasma treatment. In addition, plasma-treated water had a higher concentration of hydrogen peroxide, nitrite and nitrate when the plasma treatment time was longer. In summary, the proposed argon APPJ based on the current study could be a potential tool for treating diabetic wounds. ? 2018, The Author(s). |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85051624524&doi=10.1038%2fs41598-018-30597-1&partnerID=40&md5=d39121f3ad32527b12c42a6d5231caa8 https://scholars.lib.ntu.edu.tw/handle/123456789/592047 |
ISSN: | 2045-2322 | DOI: | 10.1038/s41598-018-30597-1 | SDG/關鍵字: | argon; catalase; glutathione peroxidase; streptozocin; superoxide dismutase; transforming growth factor beta; animal; atmospheric pressure; disease model; drug effect; experimental diabetes mellitus; male; metabolism; pharmacology; physiology; plasma gas; rat; skin; Sprague Dawley rat; wound healing; Animals; Argon; Atmospheric Pressure; Catalase; Diabetes Mellitus, Experimental; Disease Models, Animal; Glutathione Peroxidase; Male; Plasma Gases; Rats; Rats, Sprague-Dawley; Skin; Streptozocin; Superoxide Dismutase; Transforming Growth Factor beta; Wound Healing |
顯示於: | 醫學系 |
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