Simultaneous drug delivery and cellular imaging using graphene oxide
Journal
Biomaterials Science
Journal Volume
6
Journal Issue
4
Pages
813-819
Date Issued
2018
Author(s)
Abstract
Graphene oxide (GO), a derivative of graphene, and its related nanomaterials have attracted much attention in recent years due to the excellent biocompatibility and large surface area of GO with abundant oxygen functional groups, which further enable it to serve as a nano-bio interface. Herein, we demonstrate the induction of blue fluorescence in GO suspensions via a mild thermal annealing procedure. Additionally, this procedure preserves the oxygen functional groups on the graphene plane which enables the conjugation of cancer drugs without obvious cytotoxicity. Consequently, we demonstrate the capability of GO to simultaneously play the dual-role of a: (i) cellular imaging agent and (ii) drug delivery agent in CT26 cancer cells without the need for additional fluorescent protein labeling. Our method offers a simple, controllable strategy to tune and enhance the fluorescence property of GO, which shows potential for biomedical applications and fundamental studies. ? The Royal Society of Chemistry.
SDGs
Other Subjects
Biocompatibility; Controlled drug delivery; Diseases; Fluorescence; Medical applications; Oxygen; Targeted drug delivery; Biomedical applications; Blue fluorescence; Fluorescence properties; Fluorescent protein; Fundamental studies; Large surface area; Oxygen functional groups; Thermal-annealing; Graphene; cisplatin; graphene; graphene oxide; oxygen; antineoplastic agent; cisplatin; drug carrier; graphite; nanomaterial; animal cell; Article; blue light; controlled study; CT26 cell line; drug conjugation; fluorescence imaging; in vitro study; mouse; nonhuman; priority journal; suspension; animal; chemistry; fluorescence microscopy; tumor cell line; Animals; Antineoplastic Agents; Cell Line, Tumor; Cisplatin; Drug Carriers; Graphite; Mice; Microscopy, Fluorescence; Nanostructures
Publisher
Royal Society of Chemistry
Type
journal article