Increased risk of avascular necrosis in patients with psoriatic disease: A nationwide population-based matched cohort study
Journal
Journal of the American Academy of Dermatology
Journal Volume
76
Journal Issue
5
Pages
903-9100
Date Issued
2017
Author(s)
Abstract
Background Avascular necrosis (AVN) and psoriasis have some pathogenic mechanisms and associated conditions in common. Objective To examine the association between psoriasis and AVN. Methods This study used data from the Taiwan National Health Insurance Research Database for the period 2004–2006 and identified 28,268 patients with psoriasis, who were then matched for age and sex with 113,072 controls without psoriasis from the Taiwan Longitudinal Health Insurance Database 2000. Multivariate Cox proportional hazards models were used for the analysis. Results The unadjusted risk of AVN was significantly higher for patients with psoriasis than for controls (hazard ratio [HR] 2.29) and remained significant after adjustment for other risk factors (adjusted HR 1.96; 95% confidence interval 1.62-2.38). The risk for AVN increased in relation to psoriasis severity and was higher for patients with psoriasis and arthritis than for patients without arthritis. The adjusted HRs were higher for male patients than for female patients and for patients younger than 30?years compared with older patients. Limitations We lacked information on daily tobacco use, alcohol consumption, and physical activity. Conclusion The risk for AVN increased with the disease severity of psoriasis. ? 2016 American Academy of Dermatology, Inc.
SDGs
Other Subjects
bisphosphonic acid derivative; corticosteroid; cyclosporin; etretin; methotrexate; nonsteroid antiinflammatory agent; adult; alcohol consumption; alcoholism; Article; avascular necrosis; cohort analysis; comorbidity; controlled study; corticosteroid therapy; diabetes mellitus; disease association; disease severity; female; hip fracture; human; major clinical study; male; medical history; middle aged; phototherapy; physical activity; population research; priority journal; psoriasis; psoriatic arthritis; retrospective study; Taiwan; tobacco use; age; case control study; Osteonecrosis; proportional hazards model; psoriasis; risk factor; severity of illness index; sex difference; Adult; Age Factors; Case-Control Studies; Female; Humans; Male; Middle Aged; Osteonecrosis; Proportional Hazards Models; Psoriasis; Retrospective Studies; Risk Factors; Severity of Illness Index; Sex Factors; Taiwan
Publisher
Mosby Inc.
Type
journal article