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  1. NTU Scholars
  2. 醫學院
  3. 醫學系
Please use this identifier to cite or link to this item: https://scholars.lib.ntu.edu.tw/handle/123456789/592061
Title: Increased risk of avascular necrosis in patients with psoriatic disease: A nationwide population-based matched cohort study
Authors: HSIEN-YI CHIU 
Wang I.-T.
Huang W.-F.
Tsai Y.-W.
Shiu M.-N.
Tsai T.-F.
Issue Date: 2017
Publisher: Mosby Inc.
Journal Volume: 76
Journal Issue: 5
Start page/Pages: 903-9100
Source: Journal of the American Academy of Dermatology
Abstract: 
Background Avascular necrosis (AVN) and psoriasis have some pathogenic mechanisms and associated conditions in common. Objective To examine the association between psoriasis and AVN. Methods This study used data from the Taiwan National Health Insurance Research Database for the period 2004–2006 and identified 28,268 patients with psoriasis, who were then matched for age and sex with 113,072 controls without psoriasis from the Taiwan Longitudinal Health Insurance Database 2000. Multivariate Cox proportional hazards models were used for the analysis. Results The unadjusted risk of AVN was significantly higher for patients with psoriasis than for controls (hazard ratio [HR] 2.29) and remained significant after adjustment for other risk factors (adjusted HR 1.96; 95% confidence interval 1.62-2.38). The risk for AVN increased in relation to psoriasis severity and was higher for patients with psoriasis and arthritis than for patients without arthritis. The adjusted HRs were higher for male patients than for female patients and for patients younger than 30?years compared with older patients. Limitations We lacked information on daily tobacco use, alcohol consumption, and physical activity. Conclusion The risk for AVN increased with the disease severity of psoriasis. ? 2016 American Academy of Dermatology, Inc.
URI: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85008204026&doi=10.1016%2fj.jaad.2016.11.001&partnerID=40&md5=2c2eae6eba5e43ed02dee46fe7862296
https://scholars.lib.ntu.edu.tw/handle/123456789/592061
ISSN: 0190-9622
DOI: 10.1016/j.jaad.2016.11.001
metadata.dc.subject.other: bisphosphonic acid derivative; corticosteroid; cyclosporin; etretin; methotrexate; nonsteroid antiinflammatory agent; adult; alcohol consumption; alcoholism; Article; avascular necrosis; cohort analysis; comorbidity; controlled study; corticosteroid therapy; diabetes mellitus; disease association; disease severity; female; hip fracture; human; major clinical study; male; medical history; middle aged; phototherapy; physical activity; population research; priority journal; psoriasis; psoriatic arthritis; retrospective study; Taiwan; tobacco use; age; case control study; Osteonecrosis; proportional hazards model; psoriasis; risk factor; severity of illness index; sex difference; Adult; Age Factors; Case-Control Studies; Female; Humans; Male; Middle Aged; Osteonecrosis; Proportional Hazards Models; Psoriasis; Retrospective Studies; Risk Factors; Severity of Illness Index; Sex Factors; Taiwan
[SDGs]SDG3
Appears in Collections:醫學系

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臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of “NTU Repository” with “Academic Hub” to form NTU Scholars.

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