https://scholars.lib.ntu.edu.tw/handle/123456789/592386| Title: | Exploration of the Proteomic Landscape of Small Extracellular Vesicles in Serum as Biomarkers for Early Detection of Colorectal Neoplasia | Authors: | LI-CHUN CHANG Hsu, Yi-Chiung Chiu, Han-Mo Ueda, Koji Wu, Ming-Shiang Kao, Chiun-How Shen, Tang-Long |
Keywords: | biomarker; blood test; colorectal cancer; proteome; small extracellular vesicle;biomarker; blood test; colorectal cancer; proteome; small extracellular vesicle | Issue Date: | 13-Sep-2021 | Publisher: | FRONTIERS MEDIA SA | Journal Volume: | 11 | Start page/Pages: | 732743 | Source: | Frontiers in oncology | Abstract: | Patient participation in colorectal cancer (CRC) screening via a stool test and colonoscopy is suboptimal, but participation can be improved by the development of a blood test. However, the suboptimal detection abilities of blood tests for advanced neoplasia, including advanced adenoma (AA) and CRC, limit their application. We aimed to investigate the proteomic landscape of small extracellular vesicles (sEVs) from the serum of patients with colorectal neoplasia and identify specific sEV proteins that could serve as biomarkers for early diagnosis. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/592386 | ISSN: | 2234-943X | DOI: | 10.3389/fonc.2021.732743 | metadata.dc.subject.other: | acetonitrile; alternative complement pathway C3 C5 convertase; apolipoprotein; CD9 antigen; cyclic AMP dependent protein kinase; cyclic GMP phosphodiesterase; deoxycholate sodium; dithiothreitol; integrin; phosphate buffered saline; proteome; transcription factor Nrf2; actin filament; adenomatous polyp; amino acid sequence; Article; cancer staging; carcinogenesis; colonoscopy; colorectal cancer; colorectal tumor; complement system; controlled study; current smoker; disease surveillance; endocytosis; exosome; female; human; liquid chromatography-mass spectrometry; liver fibrosis; major clinical study; male; MAPK signaling; non-smoker; purine synthesis; size exclusion chromatography [SDGs]SDG3 |
| Appears in Collections: | 醫學系 |
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