Repository logo
  • English
  • 中文
Log In
Have you forgotten your password?
  1. Home
  2. College of Medicine / 醫學院
  3. School of Medicine / 醫學系
  4. Exploration of the Proteomic Landscape of Small Extracellular Vesicles in Serum as Biomarkers for Early Detection of Colorectal Neoplasia
 
  • Details

Exploration of the Proteomic Landscape of Small Extracellular Vesicles in Serum as Biomarkers for Early Detection of Colorectal Neoplasia

Journal
Frontiers in oncology
Journal Volume
11
Pages
732743
Date Issued
2021-09-13
Author(s)
LI-CHUN CHANG  
Hsu, Yi-Chiung
HAN-MO CHIU  
Ueda, Koji
MING-SHIANG WU  
Kao, Chiun-How
TANG-LONG SHEN  
DOI
10.3389/fonc.2021.732743
URI
https://scholars.lib.ntu.edu.tw/handle/123456789/592386
URL
https://scholars.lib.ntu.edu.tw/handle/123456789/585126
Abstract
Patient participation in colorectal cancer (CRC) screening via a stool test and colonoscopy is suboptimal, but participation can be improved by the development of a blood test. However, the suboptimal detection abilities of blood tests for advanced neoplasia, including advanced adenoma (AA) and CRC, limit their application. We aimed to investigate the proteomic landscape of small extracellular vesicles (sEVs) from the serum of patients with colorectal neoplasia and identify specific sEV proteins that could serve as biomarkers for early diagnosis.
Subjects
biomarker; blood test; colorectal cancer; proteome; small extracellular vesicle
SDGs

[SDGs]SDG3

Other Subjects
acetonitrile; alternative complement pathway C3 C5 convertase; apolipoprotein; CD9 antigen; cyclic AMP dependent protein kinase; cyclic GMP phosphodiesterase; deoxycholate sodium; dithiothreitol; integrin; phosphate buffered saline; proteome; transcription factor Nrf2; actin filament; adenomatous polyp; amino acid sequence; Article; cancer staging; carcinogenesis; colonoscopy; colorectal cancer; colorectal tumor; complement system; controlled study; current smoker; disease surveillance; endocytosis; exosome; female; human; liquid chromatography-mass spectrometry; liver fibrosis; major clinical study; male; MAPK signaling; non-smoker; purine synthesis; size exclusion chromatography
Publisher
FRONTIERS MEDIA SA
Type
journal article

臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of “NTU Repository” with “Academic Hub” to form NTU Scholars.

總館學科館員 (Main Library)
醫學圖書館學科館員 (Medical Library)
社會科學院辜振甫紀念圖書館學科館員 (Social Sciences Library)

開放取用是從使用者角度提升資訊取用性的社會運動,應用在學術研究上是透過將研究著作公開供使用者自由取閱,以促進學術傳播及因應期刊訂購費用逐年攀升。同時可加速研究發展、提升研究影響力,NTU Scholars即為本校的開放取用典藏(OA Archive)平台。(點選深入了解OA)

  • 請確認所上傳的全文是原創的內容,若該文件包含部分內容的版權非匯入者所有,或由第三方贊助與合作完成,請確認該版權所有者及第三方同意提供此授權。
    Please represent that the submission is your original work, and that you have the right to grant the rights to upload.
  • 若欲上傳已出版的全文電子檔,可使用Open policy finder網站查詢,以確認出版單位之版權政策。
    Please use Open policy finder to find a summary of permissions that are normally given as part of each publisher's copyright transfer agreement.
  • 網站簡介 (Quickstart Guide)
  • 使用手冊 (Instruction Manual)
  • 線上預約服務 (Booking Service)
  • 方案一:臺灣大學計算機中心帳號登入
    (With C&INC Email Account)
  • 方案二:ORCID帳號登入 (With ORCID)
  • 方案一:定期更新ORCID者,以ID匯入 (Search for identifier (ORCID))
  • 方案二:自行建檔 (Default mode Submission)
  • 方案三:學科館員協助匯入 (Email worklist to subject librarians)

Built with DSpace-CRIS software - Extension maintained and optimized by 4Science