Exploration of the Proteomic Landscape of Small Extracellular Vesicles in Serum as Biomarkers for Early Detection of Colorectal Neoplasia
Journal
Frontiers in oncology
Journal Volume
11
Pages
732743
Date Issued
2021-09-13
Author(s)
Abstract
Patient participation in colorectal cancer (CRC) screening via a stool test and colonoscopy is suboptimal, but participation can be improved by the development of a blood test. However, the suboptimal detection abilities of blood tests for advanced neoplasia, including advanced adenoma (AA) and CRC, limit their application. We aimed to investigate the proteomic landscape of small extracellular vesicles (sEVs) from the serum of patients with colorectal neoplasia and identify specific sEV proteins that could serve as biomarkers for early diagnosis.
Subjects
biomarker; blood test; colorectal cancer; proteome; small extracellular vesicle
SDGs
Other Subjects
acetonitrile; alternative complement pathway C3 C5 convertase; apolipoprotein; CD9 antigen; cyclic AMP dependent protein kinase; cyclic GMP phosphodiesterase; deoxycholate sodium; dithiothreitol; integrin; phosphate buffered saline; proteome; transcription factor Nrf2; actin filament; adenomatous polyp; amino acid sequence; Article; cancer staging; carcinogenesis; colonoscopy; colorectal cancer; colorectal tumor; complement system; controlled study; current smoker; disease surveillance; endocytosis; exosome; female; human; liquid chromatography-mass spectrometry; liver fibrosis; major clinical study; male; MAPK signaling; non-smoker; purine synthesis; size exclusion chromatography
Publisher
FRONTIERS MEDIA SA
Type
journal article