https://scholars.lib.ntu.edu.tw/handle/123456789/592604
標題: | Effects of commercial citrate-containing juices on urolithiasis in a Drosophila model | 作者: | Ho C.-Y. Chen Y.-H. Wu P.-Y. Chang C.-H. Chen H.-Y. Man K.-M. Shen J.-L. Tsai F.-J. Lin W.-Y. YUAN-JU LEE Chen W.-C. |
關鍵字: | Calcium oxalate; Citrate; Drosophila; Juice; Urolithiasis | 公開日期: | 2013 | 卷: | 29 | 期: | 9 | 起(迄)頁: | 488-493 | 來源出版物: | Kaohsiung Journal of Medical Sciences | 摘要: | Diet modification plays an important role in nephrolithiasis. Development of an easy, ready-to-use beverage such as a commercial juice drink to use as a preventive treatment for renal calculi formation would be widely welcomed. We previously developed a novel Drosophila model for the study of nephrolithiasis. It provides a new well-established drug discovery platform for this common disease. In our current study, we used the Drosophila model to investigate the preventive effects of various commercial juices as potential treatments for nephrolithiasis. Our results showed that apple, cranberry, orange, and pomegranate juices failed to reduce calcium oxalate (CaOx) crystal formation, whereas our positive control - potassium citrate (K-citrate) - significantly prevented CaOx crystal formation. Unlike the commercial fruit juices that were tested, the administration of K-citrate significantly ameliorated the ethylene glycol (EG)-induced life-span reduction in treated flies. These results indicate that EG-induced CaOx nephrolithiasis in Drosophila can be prevented by K-citrate, but not by commercial citrate-containing juices. However, the inhibitory capability of citrate-containing juices to reduce renal stone formation in humans requires further elucidation. ? 2013, Kaohsiung Medical University. Published by Elsevier Taiwan LLC. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84883822158&doi=10.1016%2fj.kjms.2013.01.003&partnerID=40&md5=57500e46025161dd5a0c6c2e363f82b4 https://scholars.lib.ntu.edu.tw/handle/123456789/592604 |
ISSN: | 1607-551X | DOI: | 10.1016/j.kjms.2013.01.003 | SDG/關鍵字: | calcium oxalate; citric acid; ethylene glycol; protective agent; animal experiment; animal model; animal tissue; apple juice; article; calcium oxalate stone; controlled study; cranberry juice; Drosophila melanogaster; drug effect; drug potentiation; microscopy; nephrolithiasis; nonhuman; orange juice; pomegranate juice; renal protection; urolithiasis; Calcium oxalate; Citrate; Drosophila; Juice; Urolithiasis; Animals; Citrates; Disease Models, Animal; Drosophila; Urolithiasis |
顯示於: | 醫學系 |
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