Mechanotransduction in fibrosis: Mechanisms and treatment targets
Journal
Current topics in membranes
Journal Volume
87
Pages
279
ISBN
9780128215197
Date Issued
2021-10-05
Author(s)
Abstract
To perceive and integrate the environmental cues, cells and tissues sense and interpret various physical forces like shear, tensile, and compression stress. Mechanotransduction involves the sensing and translation of mechanical forces into biochemical and mechanical signals to guide cell fate and achieve tissue homeostasis. Disruption of this mechanical homeostasis by tissue injury elicits multiple cellular responses leading to pathological matrix deposition and tissue stiffening, and consequent evolution toward pro-inflammatory/pro-fibrotic phenotypes, leading to tissue/organ fibrosis. This review focuses on the molecular mechanisms linking mechanotransduction to fibrosis and uncovers the potential therapeutic targets to halt or resolve fibrosis.
Subjects
Fibrosis; Mechanotransduction; Nucleocytoskeletal coupling; YAP/TAZ
SDGs
Publisher
San Diego : Academic Press
Type
journal article