https://scholars.lib.ntu.edu.tw/handle/123456789/593071
標題: | Influence of Metabolic Risk Factors on Risk of Hepatocellular Carcinoma and Liver-Related Death in Men With Chronic Hepatitis B: A Large Cohort Study | 作者: | MING-WHEI YU Lin C.-L. CHUN-JEN LIU Yang S.-H. Tseng Y.-L. Wu C.-F. |
關鍵字: | ALT; Fatty Liver; GGT; Liver Cancer | 公開日期: | 2017 | 出版社: | W.B. Saunders | 卷: | 153 | 期: | 4 | 起(迄)頁: | 1006-101700000 | 來源出版物: | Gastroenterology | 摘要: | Background & Aims Little is known about the absolute risk of hepatocellular carcinoma (HCC) and liver-disease related death, in association with metabolic risk factors, for patients with hepatitis B virus (HBV) infection. Methods We collected data from 5373 male Taiwanese civil servants who visited Taiwan's Government Employees’ Central Clinics and received routine free physical examinations from 1989 through 1992. We obtained information on liver-related morbidity and mortality in HBV carriers, 40–65 years of age (n=1690), with different metabolic risk factors. We compared their medical histories with those of study participants without HBV or HCV infection in the same age range (n=1289). We used patients’ baseline data on obesity, diabetes, hypertriglyceridemia, and high blood pressure to assign them to metabolic risk categories. We then performed a case-cohort analysis of the effects of hepatitis B viral factors on risk for HCC, based on metabolic factors and insulin resistance. Results Over a median follow-up period of 19 years, 158 of the 1690 HBV carriers developed HCC and 126 died from liver-related diseases. Among participants without HBV or HCV infection, only 6 developed HCC or died from liver-related disease. HBV carriers with different metabolic risk factors had significant differences in cumulative incidence of HCC and liver-related death. Patients with 3 or more metabolic risk factors had a substantially higher risk for HCC (10-year cumulative incidence, 13.60%) than patients with a low metabolic risk profile (10-year cumulative incidence, 4.83%; adjusted-hazard ratio, 2.32; 95% CI, 1.18–4.54). Smoking had a significant effect on this association (Pinteraction =.0044). Having 3 or more metabolic risk factors, compared with no factors, significantly increased the risk of HCC (adjusted-hazard ratio, 5.06; 95% CI, 2.23–11.47) and 10-year cumulative incidence of HCC (25.0% in smokers with 3 or more metabolic risk factors vs 3.87% in smokers with none; P <.0001) in smokers, but did not increase risk of HCC in nonsmokers. Metabolic risk factors and insulin resistance had the largest effect on HCC risk in patients with levels of HBV-DNA <10,000 copies/mL. Conclusions In a study of men with chronic HBV infection ages 40–65 years in Taiwan, we associated a high burden of metabolic risk factors with increased risk of HCC; smoking has a significant effect on this association. ? 2017 AGA Institute |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85031670161&doi=10.1053%2fj.gastro.2017.07.001&partnerID=40&md5=d5aae8183bce69430b7cd3b1d0556bf0 https://scholars.lib.ntu.edu.tw/handle/123456789/593071 |
ISSN: | 0016-5085 | DOI: | 10.1053/j.gastro.2017.07.001 | SDG/關鍵字: | alanine aminotransferase; aspartate aminotransferase; cholesterol; glucose; triacylglycerol; adult; alanine aminotransferase blood level; Article; aspartate aminotransferase blood level; body mass; cancer incidence; cancer mortality; cancer risk; cholesterol blood level; chronic hepatitis B; chronic liver disease; cohort analysis; controlled study; diabetes mellitus; follow up; glucose blood level; human; hypercholesterolemia; hypertension; hypertriglyceridemia; insulin resistance; liver cell carcinoma; major clinical study; male; morbidity; mortality; obesity; priority journal; risk factor; smoking; Taiwanese; triacylglycerol blood level; adverse effects; aged; Carcinoma, Hepatocellular; comparative study; diabetes mellitus; factual database; Hepatitis B, Chronic; hypertension; hypertriglyceridemia; incidence; Liver Neoplasms; metabolic syndrome X; middle aged; obesity; prognosis; risk assessment; Taiwan; time factor; Adult; Aged; Carcinoma, Hepatocellular; Databases, Factual; Diabetes Mellitus; Hepatitis B, Chronic; Humans; Hypertension; Hypertriglyceridemia; Incidence; Liver Neoplasms; Male; Metabolic Syndrome X; Middle Aged; Obesity; Prognosis; Risk Assessment; Risk Factors; Smoking; Taiwan; Time Factors |
顯示於: | 臨床醫學研究所 |
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