https://scholars.lib.ntu.edu.tw/handle/123456789/593169
標題: | Community and personal risk factors for hepatitis C virus infection: A survey of 23 820 residents in Taiwan in 1991-2 | 作者: | Lee M.-H. Yang H.-I. Jen C.-L. Lu S.-N. Shiou-Hwei Yeh CHUN-JEN LIU You S.-L. Sun C.-A. Wang L.-Y. WEI J. CHEN Chen C.-J. R.E.V.E.A.L.-HCV Study Group (CHYI-FENG JAN) |
公開日期: | 2011 | 卷: | 60 | 期: | 5 | 起(迄)頁: | 688-694 | 來源出版物: | Gut | 摘要: | Aim: The aim of this study was to explore the community-level risk factors, such as high hepatitis C viruse (HCV)-RNA positive rate and limited medical resources in a township, for HCV infection, one major cause of liver cirrhosis and hepatocellular carcinoma. Methods: This study enrolled 23 820 residents living in 155 villages of seven townships in Taiwan in 1991-2 to explore both individual and community risk factors for HCV infection. Antibodies against HCV (anti-HCV), HCV-RNA and HCV genotype in serum samples were determined by enzyme immunoassay, PCR and melting curve analysis, respectively. Results: The overall anti-HCV seroprevalence was 5.5%, HCV-RNA was detectable in 68.1% of the seropositives of anti-HCV, and genotype 1 was the most prevalent genotype (54.6%). Personal risk factors for the seropositivity of anti-HCV included older age, female gender, low educational level and history of blood transfusion. Based on the multilevel analysis, persons living in villages with high HCV-RNA-positive rates and limited healthcare resources had an increased seroprevalence of anti-HCV after adjustment for individual risk factors. The multivariate-adjusted prevalence OR (95% CI) was 3.49 (1.80 to 6.76) and 8.48 (5.07 to 14.20) for villages with medium and high HCV-RNA positive rate, respectively. The multivariate-adjusted OR (95% CI) was was 1.75 (0.76 to 4.01) and 3.91 (2.25 to 6.80), respectively, for villages with medium and poor healthcare resources. Conclusions: This study suggests that community risk factors contribute significantly to the variation in anti-HCV seroprevalence. It implies both the adequacy of healthcare resources and the treatment of patients positive for HCV-RNA may prevent individual residents from the acquisition of HCV infection from the community. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-79953761239&doi=10.1136%2fgut.2010.220889&partnerID=40&md5=01c101daa1eecc23bd4140c2876c734a https://scholars.lib.ntu.edu.tw/handle/123456789/593169 |
ISSN: | 0017-5749 | DOI: | 10.1136/gut.2010.220889 | SDG/關鍵字: | hepatitis C antibody; virus RNA; adult; aged; article; blood transfusion; community; education; female; gender; genotype; health survey; hepatitis C; human; liver cell carcinoma; liver cirrhosis; major clinical study; male; priority journal; risk factor; senescence; seroprevalence; Taiwan; Adult; Age Distribution; Aged; Community-Acquired Infections; Epidemiologic Methods; Female; Genotype; Hepacivirus; Hepatitis C; Hepatitis C Antibodies; Humans; Male; Middle Aged; RNA, Viral; Sex Distribution; Taiwan; Viremia |
顯示於: | 臨床醫學研究所 |
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