https://scholars.lib.ntu.edu.tw/handle/123456789/593193
標題: | Patterns of managing chronic hepatitis B treatment-related drug resistance: A survey of physicians in Mainland China, South Korea, Taiwan, and Thailand | 作者: | Chainuvati S. Cheng J. Hou J.L. Hsu C.W. Jia J.D. Komolmit P. Kwon S.Y. Lee C.H. Li H. Li Y. CHUN-JEN LIU Neo B.L. Peng C.Y. Tanwandee T. Wongcharatrawee S. Wu J.C. Yu M.L. Zhang X.X. |
關鍵字: | ALT; Antiviral resistance; Asia; Chronic hepatitis B; HBV DNA; Nucleoside/nucleotide analogs | 公開日期: | 2009 | 卷: | 3 | 期: | 3 | 起(迄)頁: | 453-460 | 來源出版物: | Hepatology International | 摘要: | Purpose: The emergence of antiviral resistance can negate the benefits of antiviral therapy in patients with chronic hepatitis B (CHB). This study aimed to assess how physicians in Asia manage suspected antiviral resistance. Methods: Randomly selected CHB-treating physicians in Mainland China, South Korea, Taiwan, and Thailand underwent a face-to-face interview. A standardized questionnaire was used to assess how physicians identify, monitor, and manage suspected resistance and its associated medical costs. Results: We interviewed 575 physicians from January to May 2008. Most physicians preferred a "prevention-of-antiviral resistance" strategy over a "rescue-once-resistance-develops" strategy. Physicians had encountered lamivudine resistance most frequently (96 - 100% of respondents), followed by the resistance to adefovir (18 - 58%) and entecavir (3 - 7%). While physicians in South Korea and Taiwan have access to resistance testing, physicians in Mainland China and Thailand have limited access to resistance testing but rely on HBV DNA and alanine aminotransferase (ALT) tests to identify resistance. Once resistance is suspected, 60% of the physicians in Mainland China, South Korea, and Thailand monitored these patients quarterly and the remaining 40% opted for monthly follow-up. In comparison, 70% of the Taiwanese physicians monitored these patients monthly. The average total direct medical costs, excluding antiviral costs, to manage a patient during the first year after suspected resistance is identified ranged from USD $319 to USD $709. Conclusions: Limited access to HBV resistance tests causes physicians in Asia to manage suspected resistance by various HBV DNA assays and ALT tests. This raises concerns that resistance may not be detected early enough to be rescued efficiently. ? Asian Pacific Association for the Study of the Liver 2009. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-68949158471&doi=10.1007%2fs12072-009-9139-9&partnerID=40&md5=18c8d1850cffe1fd9ac0a0adab1fef2f https://scholars.lib.ntu.edu.tw/handle/123456789/593193 |
ISSN: | 1936-0533 | DOI: | 10.1007/s12072-009-9139-9 | SDG/關鍵字: | adefovir; alanine aminotransferase; aspartate aminotransferase; entecavir; interferon; lamivudine; virus DNA; add on therapy; article; China; clinical trial; controlled clinical trial; controlled study; cost of illness; drug substitution; drug withdrawal; health survey; hepatitis B; Hepatitis B virus; human; managed care; patient monitoring; physician; priority journal; questionnaire; randomized controlled trial; South Korea; Taiwan; Thailand |
顯示於: | 臨床醫學研究所 |
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