https://scholars.lib.ntu.edu.tw/handle/123456789/593445
標題: | Ingested arsenic, characteristics of well water consumption and risk of different histological types of lung cancer in northeastern Taiwan | 作者: | CHI-LING CHEN Chiou H.Y. Hsu L.I. Hsueh Y.M. Wu M.M. Chen Chien-Jen C.-J. |
關鍵字: | Adenocarcinoma; Arsenic; Lung cancer; Small cell carcinoma; Squamous cell carcinoma | 公開日期: | 2010 | 卷: | 110 | 期: | 5 | 起(迄)頁: | 455-462 | 來源出版物: | Environmental Research | 摘要: | Our previous study combining two arseniasis-endemic areas in Taiwan confirmed a dose-response association of lung cancer and arsenic exposure. We conducted current analysis to elucidate the dose-response relationship in lower exposure level, and to evaluate whether the association differs in different histological types. In addition, whether specific characteristics of well water consumptions increased lung cancer risk was examined in order to establish a complete risk profile for arsenic exposure.A total of 8086 residents in northeastern Taiwan were followed for 11 years and 6888 participants remained in the final analysis because 1198 residents with unknown arsenic concentration were excluded. The 178 incident lung cancers were ascertained through linkage with the national cancer registry profiles in Taiwan. All analyses were performed by Cox's proportional hazards regression models.We found a significant dose-response trend (P=0.001) of lung cancer risk associated with increasing arsenic concentration. There was no apparent increased risk at concentrations between 10 and 100 μg/L, but concentrations between 100 and 300 μg/L showed evidence of excess risk (RR 1.54, 0.97-2.46). The relative risk was 2.25 (95% CI: 1.43, 3.55) for exposure to 300 μg/L when compared to <10 μg/L. The significant dose-response trends and the synergistic effect of arsenic exposure and cigarette smoking can be found in squamous and small cell carcinomas, but not in adenocarcinoma. Despite lacking statistical precision, when duration is accounted for, all levels of exposure including low concentration were in the direction of increased risk of lung cancer, and these associations tended to increase with longer durations of exposure.This study provides additional evidence linking arsenic to lung cancer, and the indications that arsenic may play a more important role in certain histological type may help with further research in carcinogenic effect of inorganic arsenic on lung cancer. ? 2009 Elsevier Inc. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-77953622072&doi=10.1016%2fj.envres.2009.08.010&partnerID=40&md5=fd4d351076473e5364eec6c5d3c9ea74 https://scholars.lib.ntu.edu.tw/handle/123456789/593445 |
ISSN: | 0013-9351 | DOI: | 10.1016/j.envres.2009.08.010 | SDG/關鍵字: | arsenic acid; water; arsenic; cancer; health risk; histology; pollution exposure; public health; water quality; water supply; well water; adult; article; cancer registry; cancer risk; cigarette smoking; environmental exposure; female; fluid intake; histology; human; ingestion; lung cancer; major clinical study; male; priority journal; proportional hazards model; Taiwan; Adult; Arsenic; Arsenic Poisoning; Carcinogens; Drinking; Environmental Exposure; Environmental Monitoring; Female; Humans; Lung Neoplasms; Male; Middle Aged; Risk Factors; Taiwan; Water Pollutants, Chemical; Water Supply; Taiwan |
顯示於: | 臨床醫學研究所 |
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