https://scholars.lib.ntu.edu.tw/handle/123456789/593453
標題: | Arsenic in drinking water and risk of urinary tract cancer: A follow-up study from Northeastern Taiwan | 作者: | CHI-LING CHEN Chiou H.-Y. Hsu L.-I. Hsueh Y.-M. Wu M.-M. Wang Y.-H. Chen C.-J. |
公開日期: | 2010 | 卷: | 19 | 期: | 1 | 起(迄)頁: | 101-110 | 來源出版物: | Cancer Epidemiology Biomarkers and Prevention | 摘要: | The evidence linking arsenic in drinking water with increased urinary cancer risk comes from populations in relatively high exposure areas (>100 μg/L), whereas studies from lower exposure areas (<100 μg/L) reported inconsistent results. A previous study conducted in northeastern Taiwan, where residents were exposed to relatively lower concentrations, reported increased risk of urinary cancer in a dose-response way. Using the same cohort with longer follow-up, we conducted analysis to elucidate the relationship between ingested arsenic and urinary cancer in lower exposure groups and assessed the influence of duration, recency, and latency of drinking arsenic-containing well water. A total of 8,086 residents from northeastern Taiwan were followed for 12 years. Incident urinary cancer was ascertained through linkage with the national cancer registry. All analysis was done by Cox proportional hazards regression models. There were 45 incidences of urinary cancer and a monotonic increased risk of urinary cancer was found with increasing arsenic concentration (P < 0.001). For the highly exposed (>100 μg/L), the relative risks (RR) were >5-fold, whereas the risk was elevated but not significant for low exposure (<100 μg/L). Relative to the arsenic concentration <10 μg/L, those who drank well water with higher concentration from birth [RR, 3.69; 95% confidence interval (95% CI), 1.31-10.4], still drank at enrollment (RR, 3.50; 95% CI, 1.33-9.22), and drank for >50 years (RR, 4.12; 95% CI, 1.48-11.5) had a significantly increased risk of urinary cancer. When restricted to urothelial carcinoma, all risk estimates including concentration and characteristics of well water consumption were higher. ?2010 AACR. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-74549153186&doi=10.1158%2f1055-9965.EPI-09-0333&partnerID=40&md5=25142ad98d56b1b6631296675fefa270 https://scholars.lib.ntu.edu.tw/handle/123456789/593453 |
ISSN: | 1055-9965 | DOI: | 10.1158/1055-9965.EPI-09-0333 | SDG/關鍵字: | arsenic; drinking water; adult; article; birth; cancer registry; cancer risk; environmental exposure; female; follow up; human; major clinical study; male; priority journal; Taiwan; urinary tract cancer; urogenital tract cancer; Adult; Arsenic; Arsenic Poisoning; Drinking; Environmental Exposure; Female; Follow-Up Studies; Humans; Incidence; Male; Middle Aged; Proportional Hazards Models; Risk Factors; Taiwan; Urologic Neoplasms; Water Pollutants, Chemical; Water Supply |
顯示於: | 臨床醫學研究所 |
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