Anti-DFS70 Antibodies for Differentiating Systemic Autoimmune Rheumatic Disease in Patients with Positive ANA Tests: A Systematic Review and Meta-Analysis
Journal
Diagnostics (Basel, Switzerland)
Journal Volume
11
Journal Issue
9
Pages
1592
Date Issued
2021-09-01
Author(s)
Abstract
Anti-DFS70 antibodies have been proposed as a marker to exclude systemic autoimmune rheumatic disease (SARD). We conducted this systematic diagnostic test accuracy review and meta-analysis to determine the performance of anti-DFS70 antibodies in patients with a positive anti-nuclear antibody (ANA) test result to exclude SARD. We searched PubMed, Embase, Web of Science, Scopus and the Cochrane Library up to 22 February 2021, and included studies examining the diagnostic accuracy of anti-DFS70 antibodies in patients with a positive ANA test result. The results were pooled using a hierarchical bivariate model and plotted in summary receiver operating characteristic curves. R software and Stata Statistical Software were used for the statistical analysis. Eight studies with 4168 patients were included. The summary sensitivity was 0.19 (95% confidence interval: 0.12-0.28) and the specificity was 0.93 (95% confidence interval: 0.88-0.96). The area under the curve was 0.69 (95% confidence interval: 0.64-0.72). The meta-regression analysis showed that targeting only ANA-associated rheumatic disease was associated with higher specificity. In addition, the studies with a non-SARD prevalence of <80% and using a chemiluminescence assay were associated with higher specificity. Anti-DFS70 antibodies have high specificity for the exclusion of SARD among patients presenting with a positive ANA test, but the sensitivity is low.
Subjects
ANA-associated rheumatic disease; dense fine speckled; systemic autoimmune rheumatic disease
ANA-associated rheumatic disease; Dense fine speckled; Systemic autoimmune rheumatic disease
SDGs
Other Subjects
antinuclear antibody; autoantibody; dfs70 antibody; unclassified drug; antibody specificity; chemiluminescence immunoassay; Cochrane Library; controlled study; diagnostic accuracy; diagnostic test accuracy study; differential diagnosis; genetic heterogeneity; human; Medline; meta analysis; prevalence; Review; rheumatic disease; Scopus; sensitivity and specificity; serodiagnosis; systematic review; systemic disease; Web of Science
Publisher
MDPI
Type
review