https://scholars.lib.ntu.edu.tw/handle/123456789/593930
標題: | Trogocytosis between Non-Immune Cells for Cell Clearance, and among Immune-Related Cells for Modulating Immune Responses and Autoimmunity | 作者: | KO-JEN LI CHENG-HAN WU CHENG-HSUN LU CHIEH-YU SHEN YU-MIN KUO Tsai, Chang-Youh SONG-CHOU HSIEH CHIA-LI YU |
關鍵字: | amoebic trogocytosis, cell clearance; antibody-dependent cell-mediated cytotoxicity; antigen modification; chimeric antigen receptor T lymphocyte; immune plasticity; oncologic trogocytosis; trogocytosis; tumor evasion; tumor surveillance;Amoebic trogocytosis, cell clearance; Antibody-dependent cell-mediated cytotoxicity; Antigen modification; Chimeric antigen receptor T lymphocyte; Immune plasticity; Oncologic trogocytosis; Trogocytosis; Tumor evasion; Tumor surveillance | 公開日期: | 24-二月-2021 | 出版社: | MDPI | 卷: | 22 | 期: | 5 | 起(迄)頁: | 2236 | 來源出版物: | International journal of molecular sciences | 摘要: | The term trogocytosis refers to a rapid bidirectional and active transfer of surface membrane fragment and associated proteins between cells. The trogocytosis requires cell-cell contact, and exhibits fast kinetics and the limited lifetime of the transferred molecules on the surface of the acceptor cells. The biological actions of trogocytosis include information exchange, cell clearance of unwanted tissues in embryonic development, immunoregulation, cancer surveillance/evasion, allogeneic cell survival and infectious pathogen killing or intercellular transmission. In the present review, we will extensively review all these aspects. In addition to its biological significance, aberrant trogocytosis in the immune system leading to autoimmunity and immune-mediated inflammatory diseases will also be discussed. Finally, the prospective investigations for further understanding the molecular basis of trogocytosis and its clinical applications will also be proposed. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/593930 | ISSN: | 16616596 | DOI: | 10.3390/ijms22052236 | SDG/關鍵字: | APC protein; cancer antibody; CD47 antigen; epratuzumab; HLA G antigen; immunomodulating agent; veltuzumab; allergic reaction; allograft; allotransplantation; amoeba (life cycle stage); antibody dependent cellular cytotoxicity; autoimmune disease; autoimmunity; autoinflammatory disease; basophil; CD8+ T lymphocyte; cell clearance; cell function; cell heterogeneity; cell killing; cell membrane transport; cell plasticity; cytopathogenic effect; cytotoxic T lymphocyte; dendritic cell; embryo; embryo cell; embryo development; germ cell; graft survival; human; immune evasion; immune response; immunocompetent cell; immunomodulation; immunosuppressive treatment; immunosurveillance; infectious agent; inflammation; innate immunity; mesenchymal stroma cell; natural killer cell; nonhuman; opsonization; Review; systemic lupus erythematosus; T lymphocyte; Th2 cell; trogocytosis; tumor cell; tumor immunity; tumor microenvironment; animal; antigen presentation; autoimmunity; cell communication; cell membrane; immune system; immunology; lymphocyte; lymphocyte activation; Animals; Antigen Presentation; Autoimmunity; Cell Communication; Cell Membrane; Humans; Immune System; Lymphocyte Activation; Lymphocytes |
顯示於: | 醫學系 |
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