Abnormal in vitro CXCR2 modulation and defective cationic ion transporter expression on polymorphonuclear neutrophils responsible for hyporesponsiveness to IL-8 stimulation in patients with active systemic lupus erythematosus
Journal
Rheumatology (Oxford, England)
Journal Volume
47
Journal Issue
2
Pages
150
Date Issued
2008-02
Author(s)
Abstract
To elucidate the molecular basis of hyporesponsiveness of polymorphonuclear neutrophils (PMN) to interleukin-8 (IL-8) stimulation in patients with active SLE.
Subjects
systemic lupus erythematosus; polymorphonuclear neutrophil; hyporesponsiveness; CXCR2 modulation; membrane potential; cationic ion transporters; HUMAN INTERLEUKIN-8 RECEPTOR; ACTIVATING PEPTIDE-2; CHEMOKINE RECEPTORS; SIGNAL-TRANSDUCTION; DISEASE-ACTIVITY; CELL ACTIVATION; DOWN-REGULATION; GRO-ALPHA; CHANNEL; PROTEIN
SDGs
Other Subjects
adenosine triphosphatase (potassium sodium); chemokine receptor CXCR2; interleukin 8; potassium channel; renal epithelial sodium channel; renal outer medullary epithelial potassium channel 1; sodium channel; unclassified drug; article; binding affinity; cation transport; cell surface; controlled study; down regulation; enzyme immunoassay; flow cytometry; gene expression regulation; human; human cell; immunomodulation; in vitro study; ion transport; membrane potential; nerve cell; neutrophil; priority journal; reverse transcription polymerase chain reaction; Scatchard plot; systemic lupus erythematosus; Female; Flow Cytometry; Gene Expression Regulation; Humans; Interleukin-8; Lipopolysaccharides; Lupus Erythematosus, Systemic; Male; Neutrophils; Receptors, Interleukin-8A; Receptors, Interleukin-8B; Reference Values; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger
Publisher
OXFORD UNIV PRESS
Type
journal article