https://scholars.lib.ntu.edu.tw/handle/123456789/594139
Title: | Long-term outcomes of endoscopic submucosal dissection for superficial esophageal squamous cell carcinoma in Taiwan | Authors: | Hsu M.-H. Wang W.-L. Chen T.-H. Tai C.-M. HSIU-PO WANG Lee C.-T. |
Keywords: | Endoscopic submucosal dissection; Esophageal squamous cell carcinoma; Lugol-voiding lesions | Issue Date: | 2021 | Publisher: | BioMed Central Ltd | Journal Volume: | 21 | Journal Issue: | 1 | Source: | BMC Gastroenterology | Abstract: | Background: Endoscopic submucosal dissection (ESD) is gradually turning into the standard treatment for superficial esophageal squamous cell carcinoma (SESCC), however, the long-term outcomes have hardly ever been reported outside Japan. Method: We consecutively recruited patients with SESCC who had received ESD treatment at E-Da Hospital. The demographics, pathological characteristics, and Lugol staining background pattern (type A or B: none or < 10 small Lugol-voiding lesions [LVLs]; type C or D: > 10 small or multiform LVLs) were collected, and then correlated to outcomes and survival. Results: Total of 229 lesions were enrolled and the mean lesion size was 3.28 ± 1.69 (range 1–10) cm. 72% of the lesions had a type C-D Lugol staining background pattern. After ESD, the en bloc and R0 resection rates were 93.9% and 83.5%, respectively. Forty-nine subjects developed complications, including six (2.6%) with major bleeding, two (0.9%) with perforation, and 41 (17.9%) with strictures. Pathological staging showed that 19 cases had deep submucosal cancer invasion and subsequently received adjuvant therapies. During a mean follow-up period of 52.6 (range 3–146) months, 41 patients developed metachronous recurrence. The patients with a type C-D Lugol staining background pattern were associated with a higher risk of recurrence than those with few LVLs (log-rank P = 0.019). The 10-year survival rate was more than 90%, and only eight patients died of ESCC. Conclusion: ESD has excellent long-term outcomes but a high risk of metachronous recurrence. The Lugol staining pattern over the background mucosa could offer the risk stratification of metachronous recurrence. ? 2021, The Author(s). |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111999583&doi=10.1186%2fs12876-021-01888-1&partnerID=40&md5=643242badf9152d71b6e6e8ac62307bf https://scholars.lib.ntu.edu.tw/handle/123456789/594139 |
ISSN: | 1471-230X | DOI: | 10.1186/s12876-021-01888-1 | SDG/Keyword: | adverse event; endoscopic mucosal resection; esophageal squamous cell carcinoma; esophagus tumor; human; Japan; retrospective study; Taiwan; treatment outcome; tumor recurrence; Endoscopic Mucosal Resection; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Humans; Japan; Neoplasm Recurrence, Local; Retrospective Studies; Taiwan; Treatment Outcome [SDGs]SDG3 |
Appears in Collections: | 醫學系 |
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