Divergent Functions of Tissue-Resident and Blood-Derived Macrophages in the Hemorrhagic Brain
Journal
Stroke
Journal Volume
52
Journal Issue
5
Pages
1798
Date Issued
2021
Author(s)
Goods, Brittany A
Askenase, Michael H
Beatty, Hannah E
Osherov, Artem
DeLong, Jonathan H
Hammond, Matthew D
Massey, Jordan
Landreneau, Margaret
Love, J Christopher
Sansing, Lauren H
Abstract
Brain tissue-resident microglia and monocyte-derived macrophages (MDMs) are innate immune cells that contribute to the inflammatory response, phagocytosis of debris, and tissue repair after injury. We have previously reported that both microglia and MDMs transition from proinflammatory to reparative phenotypes over days after an intracerebral hemorrhage (ICH). However, their individual functional properties in the brain remain largely unknown. Here we characterized the differences between microglia and MDMs and further elucidate their distinct activation states and functional contributions to the pathophysiology and recovery after ICH.
Subjects
cerebral hemorrhage; immunity, innate; macrophages; microglia; phagocytosis
SDGs
Publisher
LIPPINCOTT WILLIAMS & WILKINS
Type
journal article